ArticleGlycoconjugate journal2006
Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue.
Article in Glycoconjugate journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Extended receptor repertoire of an adenovirus associated with human obesity.PLoS pathogens · 2025Article
- Analysis of the intramolecular 1,7-lactone of N-acetylneuraminic acid using HPLC-MS: relationship between detection and stability.Glycoconjugate journal · 2023Article
- Sudden olfactory loss as an early marker of COVID-19: a nationwide Italian survey.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Article
- Intramolecular Lactones of Sialic Acids.International journal of molecular sciences · 2020Review
- Modified Sialic Acids on Mucus and Erythrocytes Inhibit Influenza A Virus Hemagglutinin and Neuraminidase Functions.Journal of virology · 2020Article
- Review
- Effects of Sialic Acid Modifications on Virus Binding and Infection.Trends in microbiology · 2016Review
- Tissue-Specific Glycosylation at the Glycopeptide Level.Molecular & cellular proteomics : MCP · 2015Article
- Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins.Cell reports · 2015Article
- Functions and Biosynthesis of O-Acetylated Sialic Acids.Topics in current chemistry · 2015Review
- Unified theory of bacterial sialometabolism: how and why bacteria metabolize host sialic acids.ISRN microbiology · 2013Article
- Chemoenzymatic synthesis of C8-modified sialic acids and related α2-3- and α2-6-linked sialosides.Bioorganic & medicinal chemistry letters · 2011Article
- O-Acetylated sialic acids and their role in immune defense.Advances in experimental medicine and biology · 2011Article
- Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites.The Journal of biological chemistry · 2010Article
- YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid.Journal of bacteriology · 2009Article
- The relevance of the aldehyde bisulfite toluidine blue reaction and its variants in the submicroscopic carbohydrate research.Acta histochemica · 2009Review
- Sialic acids as receptor determinants for coronaviruses.Glycoconjugate journal · 2006Review
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections by mouse hepatitis viruses result in disease of the liver, the gastrointestinal tract, respiratory tract, and the central nervous system. Coronaviruses related to mouse hepatitis virus express a hemagglutinin-esterase surface glycoprotein, which specifically hydrolyses either 5-N-acetyl-4-O-acetyl neuraminic acid (Neu4,5Ac(2)) or 5-N-acetyl-9-O-acetyl neuraminic acid (Neu5,9Ac(2)). Moreover, these sialic acids represent potential cellular receptor determinants for murine coronaviruses. Until now, the distribution of these sialic acids in mouse brain was not thoroughly investigated. Particularly Neu4,5Ac(2) was not yet found in mouse brain. Using a sensitive method of gas chromatography coupled to mass spectrometry in the electron impact mode of ionization this manuscript demonstrates the occurrence of 13 different sialic acids varying in their alkyl and acyl substituents in mouse tissues including 5-N-acetyl-4-O-acetyl-9-O-lactyl-neuraminic acid (Neu4,5Ac(2)9Lt), 5-N-acetyl-9-O-lactyl-neuraminic acid (Neu5Ac9Lt), 5-N-acetyl-8-O-methyl-neuraminic acid (Neu5Ac8Me) and the 1,7-lactone (Neu5Ac1,7L) of neuraminic acid. Neu4,5Ac(2), relatively abundant in the gut, was present as a minor compound in all tissues, including liver, olfactory lobe, telencephalon, metencephalon and hippocampus. Neu5,9Ac(2) was also found in these tissues, except in the liver. It is suggested that these sialic acids represent the endogenous substrate and receptor determinants for murine coronaviruses.
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