ReviewMedical molecular morphology2006
New trends of immunohistochemistry for making differential diagnosis of breast lesions.
Review in Medical molecular morphology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A resampling-based meta-analysis for detection of differential gene expression in breast cancer.BMC cancer · 2008Pooled it
- Combination diagnosis with elastography strain ratio and molecular markers effectively improves the diagnosis rate of small breast cancer and lymph node metastasis.Quantitative imaging in medicine and surgery · 2020Article
- Multiplex PCR analysis of apocrine lesions shows frequent PI3K-AKT pathway mutations in both benign and malignant apocrine breast tumors.Medical molecular morphology · 2020Article
- The Ras-related gene ERAS is involved in human and murine breast cancer.Scientific reports · 2018Article
- Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast.SAGE open medicine · 2018Article
- Application of Returned Cell Block Method (Cell Block from a Papanicolaou Staining Smear on a Glass Slide) for the Evaluation of Fine Needle Aspiration Cytology of Tumors of the Breast.Diagnostic cytopathology · 2016Article
- Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.Molecular & cellular proteomics : MCP · 2016Article
- In stage II/III lymph node-positive breast cancer patients less than 55 years of age, keratin 8 expression in lymph node metastases but not in the primary tumour is an indicator of better survival.Virchows Archiv : an international journal of pathology · 2015Article
- Application of a high throughput method of biomarker discovery to improvement of the EarlyCDT(®)-Lung Test.PloS one · 2012Article
- Effects of short-term estrogen treatment on the progression of N-methyl-N-nitrosourea-induced premalignant mammary lesions in female Lewis rats.Medical molecular morphology · 2011Article
- Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Androgens in human breast carcinoma.Medical molecular morphology · 2010Review
- Molecular morphological approach to the pathological study of development and advancement of human breast cancer.Medical molecular morphology · 2010Review
- Solid papillary carcinoma of the breast: imprint cytological and histological findings.Medical molecular morphology · 2010Article
- Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease.Molecular oncology · 2007Article
- In situ production of sex steroids in human breast carcinoma.Medical molecular morphology · 2007Review
- Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia.Molecular oncology · 2007Article
- A novel myoepithelial/progenitor cell marker in the breast?Virchows Archiv : an international journal of pathology · 2007Article
- Multistep mouse mammary tumorigenesis through pre-neoplasia to neoplasia and acquisition of metastatic potential.Medical molecular morphology · 2007Review
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Immunohistochemistry is widely used for pathological diagnosis of breast lesions. Other than hormone receptors and HER2/neu analysis for primary breast carcinomas, several markers may be useful for differential diagnoses, although in limited situations. To decide the malignant potential of intraductal proliferative lesions, analysis for the staining pattern of cytokeratins may be a good reference. Most ductal carcinoma in situ cases are diffusely positive for luminal cell markers (CK8, CK18, CK19), but negative for basal cell markers (CK5/6 and CK14). However, usual ductal hyperplasia may show the mosaic staining patterns for any of these markers, which may indicate a heterogeneous cell population in benign lesions. Myoepithelial markers (alpha-SMA, myosin, calponin, p63, CD10) are almost consistently positive for benign papillomas but they do not completely distinguish intraductal papillary carcinomas. Preservation of myoepithelial layer is the diagnostic key when looking at benign sclerosing lesions, including carcinoma with pseudoinvasive structures. E-cadherin is mostly positive for ductal carcinomas but negative for lobular carcinomas. Some of the lobular carcinomas are positive for 34betaE12, but they are consistently negative for CK5/6. Comparison with histopathological findings of hematoxylin and eosin is essential to make proper diagnosis in the individual case.
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