ReviewJournal of neurochemistry2006
NFkappaB in neurons? The uncertainty principle in neurobiology.
Review in Journal of neurochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Review
- Nitroxidative Stress, Cell-Signaling Pathways, and Manganese Porphyrins: Therapeutic Potential in Neuropathic Pain.International journal of molecular sciences · 2025Review
- NF-KappaB Pathway Is Involved in Bone Marrow Stromal Cell-Produced Pain Relief.Frontiers in integrative neuroscience · 2018Article
- Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways.Scientific reports · 2017Article
- Lipopolysacharide Rapidly and Completely Suppresses AgRP Neuron-Mediated Food Intake in Male Mice.Endocrinology · 2016Article
- NFκB-inducing kinase inhibits NFκB activity specifically in neurons of the CNS.Journal of neurochemistry · 2016Article
- Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease.Journal of neurochemistry · 2016Review
- Reducing effect of IL-32α in the development of stroke through blocking of NF-κB, but enhancement of STAT3 pathways.Molecular neurobiology · 2015Article
- Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats.Frontiers in behavioral neuroscience · 2014Article
- Modulation of pineal melatonin synthesis by glutamate involves paracrine interactions between pinealocytes and astrocytes through NF-κB activation.BioMed research international · 2013Article
- Promoter polymorphisms in two overlapping 6p25 genes implicate mitochondrial proteins in cognitive deficit in schizophrenia.Molecular psychiatry · 2012Article
- NFκB signaling regulates embryonic and adult neurogenesis.Frontiers in biology · 2012Article
- NF-κB activity in perinatal brain during infectious and hypoxic-ischemic insults revealed by a reporter mouse.Brain pathology (Zurich, Switzerland) · 2012Article
- Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients.Clinical immunology (Orlando, Fla.) · 2012Article
- Neuronal responses to physiological stress.Frontiers in genetics · 2012Article
- Mechanisms of specificity in neuronal activity-regulated gene transcription.Progress in neurobiology · 2011Review
- Induction of innate immune genes in brain create the neurobiology of addiction.Brain, behavior, and immunity · 2011Review
- Interleukin-10 provides direct trophic support to neurons.Journal of neurochemistry · 2009Article
- Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Unique aspects of transcriptional regulation in neurons--nuances in NFkappaB and Sp1-related factors.Journal of neuroinflammation · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Nuclear factor kappaB (NFkappaB) is a dynamically modulated transcription factor with an extensive literature pertaining to widespread actions across species, cell types and developmental stages. Analysis of NFkappaB in a complex environment such as neural tissue suffers from a difficulty in simultaneously establishing both activity and location. Much of the available data indicate a profound recalcitrance of NFkappaB activation in neurons, as compared with most other cell types. Few studies to date have sought to distinguish between the various combinatorial dimers of NFkappaB family members. Recent research has illuminated the importance of these problems, as well as opportunities to move past them to the nuances manifest through variable activation pathways, subunit complexity and target sequence preferences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.