ArticleCell stress & chaperones2006
Heat shock protein 70 binds its own messenger ribonucleic acid as part of a gene expression self-limiting mechanism.
Article in Cell stress & chaperones, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Fever-Induced Heat Shock Protein-70 Regulates Macrophage IL-1β and IL-10 Secretion During Mycobacterium tuberculosis Infection.European journal of immunology · 2025Article
- RNA-dependent proteome solubility maintenance inRNA biology · 2024Article
- Small Heat Shock Protein (sHsp22.98) fromViruses · 2023Article
- The interaction of heat shock proteins with cellular membranes: a historical perspective.Cell stress & chaperones · 2021Review
- Effect of in-vitro heat stress challenge on the function of blood mononuclear cells from dairy cattle ranked as high, average and low immune responders.BMC veterinary research · 2021Article
- What's Genetic Variation Got to Do with It? Starvation-Induced Self-Fertilization Enhances Survival in Paramecium.Genome biology and evolution · 2020Article
- Imaging Single mRNA Molecules in Mammalian Cells Using an Optimized MS2-MCP System.Methods in molecular biology (Clifton, N.J.) · 2019Article
- HSP70 in human polymorphonuclear and mononuclear leukocytes: comparison of the protein content and transcriptional activity of HSPA genes.Cell stress & chaperones · 2017Article
- Article
- Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein.Nucleic acids research · 2013Article
- Magnetic field-controlled gene expression in encapsulated cells.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Effects of simulated weightlessness on liver Hsp70 and Hsp70mRNA expression in rats.International journal of clinical and experimental medicine · 2010Article
- Towards a dynamical network view of brain ischemia and reperfusion. Part II: a post-ischemic neuronal state space.Journal of experimental stroke & translational medicine · 2010Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of heat shock proteins is a cellular response to a variety of stressors. HSP70, the major stress-induced heat shock protein, is involved in repair and protection after the insult. However, the prolonged presence of this protein is detrimental. Consequently, Hsp70 expression must be tightly regulated. We have previously shown an increase in the degradation of Hsp70 messenger ribonucleic acid (mRNA) paralleling the accumulation of HSP70. Incubation of cells with transcriptional and translational inhibitors after heat shock resulted in a significant reduction in Hsp70 mRNA degradation. These observations suggest that newly synthesized, stress-induced factors might be involved in the decay of Hsp70 mRNA. We found that HSP70 binds directly to Hsp70 mRNA, as demonstrated by immunoprecipitation. This observation was confirmed by RNA gel-shift assays. These results are evidence for a novel and likely direct interaction between HSP70 and Hsp70 mRNA in cells after stress. This interaction may be part of a self-limiting mechanism to reduce HSP70 production, thus avoiding potential toxic effects of this protein in the absence of stress.
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