ArticleCell stress & chaperones2006
Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors.
Article in Cell stress & chaperones, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis.BMC gastroenterology · 2021Pooled it
- Label-free LC-MS analysis of HER2+ breast cancer cell line response to HER2 inhibitor treatment.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015Article
- Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity.Oncogene · 2015Article
- Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.Cell stress & chaperones · 2014Article
- Article
- Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study.Histochemistry and cell biology · 2011Article
- Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.Oncogene · 2010Article
- HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness.Cell stress & chaperones · 2009Article
- Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia.Leukemia research · 2009Article
- HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer.Molecular biotechnology · 2008Article
- Serum proteome analysis for profiling protein markers associated with carcinogenesis and lymph node metastasis in nasopharyngeal carcinoma.Clinical & experimental metastasis · 2008Article
- Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses.Cell stress & chaperones · 2006Article
- Heat shock protein 70 and glycoprotein 96 are differentially expressed on the surface of malignant and nonmalignant breast cells.Cell stress & chaperones · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock protein (Hsp)-peptide complexes purified from tumors can prime the immune system against tumor antigens, but how they contribute to the generation of immune responses against naturally occurring tumors is unknown. Murine tumors expressing high amounts of Hsp70 are preferentially rejected by the immune system, suggesting that low Hsp70 expression is advantageous for tumor growth in the host. To determine whether Hsp70 was differentially expressed in human tumors, inducible Hsp70 expression was quantitatively (by Western blot) and qualitatively (by immunohistology) analyzed in 53 biopsies of tumor and normal breast tissue. The mean expression of inducible Hsp70 was significantly higher in tumor compared with normal tissue (U = 899.0; P = 0.0033). However, a significant negative association of the amount of Hsp70 expressed by tumor tissue was found with metastasis (r = -0.309; P = 0.05). After 3 years, follow-up analysis determined that 7 of the 53 patients relapsed, and 5 died. Hsp70 expression in tumor (but not normal) cells was significantly lower in relapse patients and patients with metastatic disease than in patients with no relapse or metastasis. Together, these observations support the hypothesis that Hsp70 plays a role in tumor expansion in vivo, and tumors that downregulate it may be able to evade immunosurveillance and grow.
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