ArticleImmunogenetics2006
Study of Cynomolgus monkey (Macaca fascicularis) MhcDRB (Mafa-DRB) polymorphism in two populations.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 61 citations in OpenAlex.
- Review
- Cynomolgus macaque IL37 polymorphism and control of SIV infection.Scientific reports · 2019Article
- Whole genome sequencing in the search for genes associated with the control of SIV infection in the Mauritian macaque model.Scientific reports · 2018Article
- MHC-identical and transgenic cynomolgus macaques for preclinical studies.Inflammation and regeneration · 2018Review
- Ancestry, Plasmodium cynomolgi prevalence and rhesus macaque admixture in cynomolgus macaques (Macaca fascicularis) bred for export in Chinese breeding farms.Journal of medical primatology · 2017Article
- Identification of MHC Haplotypes Associated with Drug-induced Hypersensitivity Reactions in Cynomolgus Monkeys.Toxicologic pathology · 2017Article
- Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque.Frontiers in immunology · 2017Article
- Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing: Mafa-class I polymorphism.Immunogenetics · 2015Article
- MHC polymorphism in Caribbean African green monkeys.Immunogenetics · 2014Article
- Study of MHC class II region polymorphism in the Filipino cynomolgus macaque population.Immunogenetics · 2014Article
- Deleterious impact of feto-maternal MHC compatibility on the success of pregnancy in a macaque model.Immunogenetics · 2014Article
- Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.Immunogenetics · 2013Article
- Population and landscape genetics of an introduced species (M. fascicularis) on the island of Mauritius.PloS one · 2013Article
- Haplessly hoping: macaque major histocompatibility complex made easy.ILAR journal · 2013Review
- Evolution of HLA-DRB genes.Molecular biology and evolution · 2012Article
- Study of cynomolgus monkey (Macaca fascicularis) Mhc DRB gene polymorphism in four populations.Immunogenetics · 2012Article
- Comprehensive identification of high-frequency and co-occurring Mafa-B, Mafa-DQB1, and Mafa-DRB alleles in cynomolgus macaques of Vietnamese origin.Human immunology · 2012Article
- DR haplotype diversity of the cynomolgus macaque as defined by its transcriptome.Immunogenetics · 2012Article
- Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques.Immunogenetics · 2011Article
- Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque.Immunogenetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cynomolgus monkey is one of the macaque species currently used as an animal model for experimental surgery and medicine, in particular, to experiment new drugs or therapy protocols designed for the prevention of allograft rejection. In this field, it is of utmost importance to select histoincompatible recipient-donor pairs. One way to ensure incompatibility between donor and recipient is to check their major histocompatibility complex (MHC) genotypes at the loci playing a determinant role in histocompatibility. We report in this paper on the cynomolgus monkey DRB polymorphism evidenced by sequencing of amplified exon 2 separated either by denaturing gradient gel electrophoresis (DGGE), or by cloning. By the study of 253 unrelated animals from two populations (Mauritius and The Philippines), we characterized 50 exon 2 sequences among which 28 were identical to sequences already reported in Macaca fascicularis or other macaque species (Macaca mulatta, Macaca nemestrina). By cloning and sequencing DRB cDNA, we revealed two additional DRB alleles. Out of the 20 haplotypes that we defined here, only two were found in both populations. The functional impact of DR incompatibility was studied in vitro by mixed lymphocyte culture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.