Trial reportPsychopharmacology2006
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam.
Trial report in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 41 citations in OpenAlex.
- Lorazepam Challenge for Individuals at Varying Genetic Risk for Alzheimer Disease.Alzheimer disease and associated disordersTrial
- Computerized tests to evaluate recovery of cognitive function after deep sedation with propofol and remifentanil for colonoscopy.Journal of clinical monitoring and computing · 2019Observational
- Adjuvant ovarian function suppression and cognitive function in women with breast cancer.British journal of cancer · 2016Article
- Designing and evaluating Brain Powered Games for cognitive training and rehabilitation in at-risk African children.Global mental health (Cambridge, England) · 2015Article
- Behavior at the choice point: decision making in hidden pathway maze learning.Neuropsychology review · 2014Review
- Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy.Neuropsychiatric disease and treatment · 2012Article
- Cognitive function in patients undergoing coronary angiography.Heart Asia · 2010Article
- Methodological improvements in quantifying cognitive change in clinical trials: an example with single-dose administration of donepezil.The journal of nutrition, health & aging · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which the sample was drawn. However, the magnitude and pharmacodynamic qualities of the response to many central nervous system-active drugs are known to vary in the population. Therefore, it is useful to consider statistical models for the detection of cognitive change in response to a drug treatment in individual subjects. MATERIALS AND
methodsIn this report, we first outline the statistical assumptions and requirements for the reliable estimation of clinically relevant individual change in cognition. We then used the sedative benzodiazepine, alprazolam, as a pharmacologic challenge in healthy volunteer subjects to test our statistical model, using a parallel groups placebo-controlled study design. After treatment, the nature and severity of alprazolam-induced cognitive change was determined for each individual.
resultsOur proposed method and analysis showed an excellent sensitivity and specificity for alprazolam-related cognitive deterioration in individuals. DISCUSSION AND
conclusionsThese findings, although preliminary, suggest that statistically reliable decisions about the effects of sedative drugs on cognition can be made for individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.