Evidence map›Paper›PMID 16572260›Full record

ArticleNeurochemical research2006

Molecular analysis of the magnocellular neuroendocrine phenotype: from the micropunch to laser microdissection.

Noriko Mutsuga, Harold Gainer

Abstract read
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In one paragraph

Article in Neurochemical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Noriko MutsugaMolecular Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Harold Gainer

Funding

PEPTIDES IN THE ADULT AND DEVELOPING VERTEBRATE NERVOUS SYSTEMSZ01NS002723 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GAINER, HAROLD · 1987 to 2008
$7.0M
Regulation of Oxytocin and Vasopressin Gene Expression in the hypothalamus.ZIANS002723 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GAINER, HAROLD · 2009 to 2012
$4.1M
Intramural NIH HHS
6 · The paper itself

Abstract

Microdissection of selected regions of central nervous system (CNS) has provided the basis of modern chemoarchitectonics. Laser microdissection is a modern variant of the "Palkovits punch" technique and used together with gene array analysis has revolutionalized CNS molecular analysis. Here we describe the use of such an approach to elucidate molecules selectively expressed in magnocellular neuroendocrine cells (MCNs) in the supraoptic nucleus (SON). We found 123 genes that are preferentially expressed in the SON, and of these, 89 were substantially osmoregulated in their expression. One of these, C1q domain containing 1, is a novel gene that is osmoregulated much more than even vasopressin itself.

Indexed as

Gene Expression ProfilingAnimalsBase SequenceDissectionDNA PrimersLasersMaleNeurosecretory SystemsNucleic Acid HybridizationPhenotypeRatsRats, Sprague-DawleyDNA Primers

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.