ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders.Protein & cell · 2022Review
- SOX10-regulated promoter use defines isoform-specific gene expression in Schwann cells.BMC genomics · 2020Article
- YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells.Developmental cell · 2019Article
- Posterior tibial nerve schwannoma in a multiple myeloma patient: A case report.SAGE open medical case reports · 2019Article
- Why are olfactory ensheathing cell tumors so rare?Cancer cell international · 2019Review
- The importance of nerve microenvironment for schwannoma development.Acta neuropathologica · 2016Article
- Role of Merlin/NF2 inactivation in tumor biology.Oncogene · 2016Review
- Article
- Schwannomas and their pathogenesis.Brain pathology (Zurich, Switzerland) · 2014Review
- FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.The Journal of biological chemistry · 2013Article
- The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway.Oncogene · 2013Article
- Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.Brain : a journal of neurology · 2013Article
- Lck tyrosine kinase mediates β1-integrin signalling to regulate Schwann cell migration and myelination.Nature communications · 2013Article
- Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length.Molecular and cellular neurosciences · 2011Article
- Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer.Biochemical pharmacology · 2010Review
- NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation.Oncogene · 2010Article
- Article
- PAK kinase regulates Rac GTPase and is a potential target in human schwannomas.Experimental neurology · 2009Article
- Laminin is required for Schwann cell morphogenesis.Journal of cell science · 2009Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Schwann cell-axon interaction is the hallmark feature of peripheral nerves, yet the intracellular signals underlying this interaction are unknown. Schwann cells extend processes and migrate on developing axons before differentiation, requiring coordinated regulation of the Schwann cell cytoskeleton. Small GTPases of the Rho family, including Rho, Rac, and cell division cycle 42, regulate the actin cytoskeleton. The neurofibromatosis type 2 (NF2) gene is commonly mutated in schwannomas, Schwann cell tumors that contain cells lacking axon interaction. NF2 is involved in suppression of Rac signaling, and cultured schwannoma cells contain elevated, GTP-bound, active Rac. Despite these previous studies, a causal relationship between Rac activation and the abnormal cellular morphology of schwannoma is unknown. We used fluorescence resonance energy transfer to follow Rac activity in normal human Schwann cells and schwannoma cells during interaction with neurons. Normal Schwann cells elongated processes along neurites under low Rac activity. Schwannoma cells showed high Rac activity at distal regions of the cells and failed to align processes with neurites. Application of a Rac-specific inhibitor, the chemical compound NSC23766, to schwannoma cells restored neuronal interaction. The data support the significance of regulated Rac signaling in mediating Schwann cell-axon interaction and suggest that controlling Rac activity as a possible therapy for schwannomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.