ArticleHuman reproduction (Oxford, England)2006
The human cumulus--oocyte complex gene-expression profile.
Article in Human reproduction (Oxford, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 288 citations in OpenAlex.
- A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas.Stem cells (Dayton, Ohio) · 2007Pooled it
- Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications.Human reproduction updatePooled it
- Effects of Testosterone on Cumulus Cells Gene Expression in Patients with Diminished Ovarian Reserve.Reproductive sciences (Thousand Oaks, Calif.) · 2025Trial
- A randomized controlled trial of gonadotropin-releasing hormone agonist versus gonadotropin-releasing hormone antagonist in Iranian infertile couples: oocyte gene expression.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014Trial
- Comprehensive whole-genome sequencing of an early-stage primary myelofibrosis patient defines low mutational burden and non-recurrent candidate genes.Haematologica · 2013Trial
- Trial
- Standardizing Cell Ontology terms for cross-study integration in the female reproductive tract.Science advances · 2026Review
- Candidate microRNA networks in cyclophosphamide-associated ovarian injury and premature ovarian insufficiency: a structured narrative review.Journal of ovarian research · 2026Review
- Lipid remodeling and circulating semaphorin 3A in diminished ovarian reserve.Scientific reports · 2026Article
- Impact of trigger-day serum luteinizing hormone levels on embryo quality and pregnancy outcomes in overweight and obese women undergoing GnRH antagonist protocols: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Advances, Mechanisms, and Clinical Perspectives for the In Vitro Maturation of Human Oocytes.International journal of molecular sciences · 2025Review
- Transcriptional Changes in Cumulus Cells During In Vitro Maturation of Human Oocytes.Molecular reproduction and development · 2025Article
- Secretory Profile Analysis of Human Granulosa Cell Line Following Gonadotropin Stimulation.International journal of molecular sciences · 2025Article
- Granulosa cell transcription is similarly impacted by superovulation and aging and predicts early embryonic trajectories.Nature communications · 2025Article
- Maturational competence of equine oocytes is associated with alterations in their 'cumulome'.Molecular human reproduction · 2024Article
- Novel PATL2 variants cause female infertility with oocyte maturation defect.Journal of assisted reproduction and genetics · 2024Article
- RAD51 and Infertility: A Review and Case-Control Study.Biochemical genetics · 2024Review
- The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women.BMC medical genomics · 2024Article
- Lipid metabolites, interleukin-6 and oxidative stress markers in follicular fluid and their association with serum concentrations in mares.Veterinary research communications · 2023Article
- Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe understanding of the mechanisms regulating human oocyte maturation is still rudimentary. We have identified transcripts differentially expressed between immature and mature oocytes and cumulus cells.
methodsUsing oligonucleotide microarrays, genome-wide gene expression was studied in pooled immature and mature oocytes or cumulus cells from patients who underwent IVF.
resultsIn addition to known genes, such as DAZL, BMP15 or GDF9, oocytes up-regulated 1514 genes. We show that PTTG3 and AURKC are respectively the securin and the Aurora kinase preferentially expressed during oocyte meiosis. Strikingly, oocytes overexpressed previously unreported growth factors such as TNFSF13/APRIL, FGF9, FGF14 and IL4 and transcription factors including OTX2, SOX15 and SOX30. Conversely, cumulus cells, in addition to known genes such as LHCGR or BMPR2, overexpressed cell-to-cell signalling genes including TNFSF11/RANKL, numerous complement components, semaphorins (SEMA3A, SEMA6A and SEMA6D) and CD genes such as CD200. We also identified 52 genes progressively increasing during oocyte maturation, including CDC25A and SOCS7.
conclusionThe identification of genes that were up- and down-regulated during oocyte maturation greatly improves our understanding of oocyte biology and will provide new markers that signal viable and competent oocytes. Furthermore, genes found expressed in cumulus cells are potential markers of granulosa cell tumours.
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