ArticleCerebrospinal fluid research2006
Cerebrospinal fluid adenosine deaminase activity: a complimentary tool in the early diagnosis of tuberculous meningitis.
Article in Cerebrospinal fluid research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 80 citations in OpenAlex.
- Review
- Meningitis-retention syndrome: a review and update of an unrecognized clinical condition.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- Tubercular skull base osteomyelitis - A case report.IDCases · 2022Article
- The use of real-time polymerase chain reaction and an adenosine deaminase assay for diagnosing pleural tuberculosis.African journal of laboratory medicine · 2019Article
- Determination and Validation of a Lower Cut Off Value of Cerebrospinal Fluid Adenosine Deaminase (CSF-ADA) Activity in Diagnosis of Tuberculous Meningitis.Journal of clinical and diagnostic research : JCDR · 2017Article
- An enzymatic assay for high-throughput screening of cytidine-producing microbial strains.PloS one · 2015Article
- Article
- A Five Years Study of Tuberculous Meningitis in Iran.Iranian journal of pathology · 2015Article
- A Hospital Based Study on Estimation of Adenosine Deaminase Activity (ADA) in Cerebrospinal Fluid (CSF) in Various Types of Meningitis.Journal of clinical and diagnostic research : JCDR · 2014Article
- Laboratory investigations on the diagnosis of tuberculosis in the malnourished tribal population of melghat, India.PloS one · 2013Article
- Quantitative proteomics for identifying biomarkers for tuberculous meningitis.Clinical proteomics · 2012Article
- Sensitivity and specificity of immunocytochemical staining of mycobacterial antigens in the cytoplasm of cerebrospinal fluid macrophages for diagnosing tuberculous meningitis.Journal of clinical microbiology · 2011Article
- Central nervous system tuberculosis.African health sciences · 2011Review
- Adenosine Deaminase Levels in CSF of Tuberculous Meningitis Patients.Journal of clinical medicine research · 2010Article
- Central nervous system tuberculosis: pathogenesis and clinical aspects.Clinical microbiology reviews · 2008Review
- Evaluation of the IS6110 PCR assay for the rapid diagnosis of tuberculous meningitis.Cerebrospinal fluid research · 2007Article
- Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System.Basic and clinical neuroscienceArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculous meningitis (TBM) is the commonest form of neurotuberculosis caused by Mycobacterium tuberculosis bacilli (MTB). The diagnosis of TBM is often difficult. A reliable, cost-effective and rapid diagnostic test, which can be performed in any standard pathology laboratory, could be of help in the diagnosis of TBM. In the present study we measured the adenosine deaminase (ADA) activity in cerebrospinal fluid (CSF) of TBM and non-TBM patients.
methodADA activity in CSF was determined according to a method based on the Berthlot reaction, which is the formation of a colored indophenol complex from ammonia liberated from adenosine, and quantified spectrophotometrically.
resultsThe CSF ADA activity from TBM patients was compared with CSF ADA from non-TBM infectious meningitis patients, and from patients with non-infectious neurological disorders. The mean CSF ADA activity was found to be significantly higher in CSF of TBM patients, 14.31 +/- 3.87 (2.99-26.94), mean +/- SD with range, than in the CSF from non-TBM infectious meningitis, 9.25 +/- 2.14 (4.99-13.96) and from the non-infectious neurological disorders group, 2.71 +/- 1.96 (0.00-7.68), P < 0.0001 for both comparisons. A cut-off value of 11.39 U/L/min for the TBM patients was calculated from the mean + SD of the non-TBM patients. The ADA test gave a sensitivity of 82% and a specificity of 83% for infectious TBM when this cut-off value was used.
conclusionThis study demonstrated that ADA activity in the CSF of TBM patients, using a cut-off value 11.39 U/L/min, can be useful for the early differential diagnosis of TBM. This test can be performed in any pathology laboratory where more sophisticated methods are not available.
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