ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2006
Pediatric cerebellar pleomorphic xanthoastrocytoma with anaplastic features: a case of long-term survival after multimodality therapy.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 33 citations in OpenAlex.
- Clinical outcomes for pleomorphic xanthoastrocytoma patients.Neuro-oncology practice · 2025Article
- Clinical features and surgical outcomes of high grade pleomorphic xanthoastrocytomas: a single-center experience with a systematic review.Frontiers in oncology · 2023Article
- Demography, Pattern of Care, and Survival in Patients with Xanthoastrocytoma: A Systematic Review and Individual Patient Data Analysis of 325 Cases.Journal of neurosciences in rural practice · 2019Article
- Suprasellar pleomorphic xanthoastrocytoma: A case report.Surgical neurology international · 2019Article
- MR Imaging Features of Anaplastic Pleomorphic Xanthoastrocytoma Mimicking High-Grade Astrocytoma.AJNR. American journal of neuroradiology · 2018Article
- Article
- Pleomorphic Xanthoastrocytoma: Natural History and Long-Term Follow-Up.Brain pathology (Zurich, Switzerland) · 2015Article
- Atypical pleomorphic neoplasms of the pineal gland: Case report and review of the literature.Surgical neurology international · 2015Article
- Pleomorphic xanthoastrocytoma with malignant transformation and multiple recurrences in an Iranian girl.BMJ case reports · 2012Article
- BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.PloS one · 2011Article
- Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature.Journal of neuro-oncology · 2009Review
- A case series of pediatric survivors of anaplastic pleomorphic xanthoastrocytoma.Neuro-oncology advancesArticle
- Pleomorphic Xanthoastrocytoma; Clinicopathological spectrum of An Intriguing neoplasm.Pakistan journal of medical sciencesArticle
- Pleomorphic xanthoastrocytoma with anaplastic features: A rare case report and review of literature with reference to current management.Asian journal of neurosurgeryArticle
- A Recurrent Pleomorphic Xanthoastrocytoma in the Cerebellum in a Young Adult: A Case Report and Review of the Literature.Case reports in neurologyArticle
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
case reportA 4-year-old girl had a large midline cerebellar solid and cystic mass partially attached to the meninges. The original diagnosis was glioblastoma multiforme and she was treated by a gross-total surgical resection followed by chemotherapy and radiation therapy to the posterior fossa during the ensuing 14 months. She has received no further therapy and appears to be doing well 12 years later. This unusual favorable clinical outcome prompted our review of this case.
methodsAdditional special stains and immunocytochemistry were performed on the paraffin embedded tumor sections.
resultsWe have confirmed the original histopathological observations of hypercellularity and focal nuclear pleomorphism, atypical mitoses, vascular hyperplasia, as well as focal necrosis. However, the additional stains revealed that the tumor is a relatively well-circumscribed meningeal-based astrocytic tumor (positive for GFAP) with extensive reticulin deposit and focal neuronal differentiation (positive for synaptophysin). A Ki67 labeling index is generally very low, but is positive in up to 5-10% of tumor cells focally. In the light of the favorable clinical outcome and the overall histological features, this tumor may be best reclassified as a rare example of cerebellar pleomorphic xanthoastrocytoma with foci of anaplasia.
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