ArticleDiabetologia2006
Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes.International journal of molecular sciences · 2024Review
- The intestine as an endocrine organ and the role of gut hormones in metabolic regulation.Nature reviews. Gastroenterology & hepatology · 2023Review
- Pax4-Ghrelin mediates the conversion of pancreatic ε-cells to β-cells after extreme β-cell loss in zebrafish.Development (Cambridge, England) · 2023Article
- Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story.International journal of molecular sciences · 2023Review
- Diverse and Complementary Effects of Ghrelin and Obestatin.Biomolecules · 2022Review
- Article
- Overweight and obesity in type 1 diabetes is not associated with higher ghrelin concentrations.Diabetology & metabolic syndrome · 2021Article
- Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition.Journal of lipid research · 2020Article
- Recombinant betatrophin (Angptl‑8/lipasin) ameliorates streptozotocin‑induced hyperglycemia and β‑cell destruction in neonatal rats.Molecular medicine reports · 2019Article
- Ghrelin regulation of glucose metabolism.Journal of neuroendocrinology · 2019Review
- Reprogramming Cells to Make Insulin.Journal of the Endocrine Society · 2019Review
- Development and Characteristics of Pancreatic Epsilon Cells.International journal of molecular sciences · 2019Review
- Ghrelin regulation of glucose metabolism.Peptides · 2018Review
- Ghrelin.Molecular metabolism · 2015Review
- Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases.Endocrine · 2015Review
- Ghrelin-ghrelin O-acyltransferase system in the pathogenesis of nonalcoholic fatty liver disease.World journal of gastroenterology · 2015Review
- Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality.International journal of endocrinology · 2015Article
- Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms.Cardiovascular diabetology · 2012Article
- Ghrelin's second life: from appetite stimulator to glucose regulator.World journal of gastroenterology · 2012Review
- Alcoholism and diabetes mellitus.Diabetes & metabolism journal · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisGhrelin, a stomach-derived hormone, functions in multiple biological processes, including glucose metabolism and cellular differentiation and proliferation. In this study, we examined whether early treatment with ghrelin can regenerate beta cells of the pancreas in an animal model of diabetes mellitus, the n0-STZ model, in which neonatal rats are injected with streptozotocin (STZ) at birth.
methodsFollowing administration of ghrelin to n0-STZ rats from postnatal days 2 to 8, we examined beta cell mass, mRNA expression levels of insulin and of pancreatic and duodenal homeobox 1 (Pdx1) gene, and pancreatic morphology on days 21 and 70. In addition, we investigated the effects of ghrelin on beta cell replication.
resultsBy day 21, ghrelin treatment increased pancreatic expression of insulin and Pdx1 mRNA in n0-STZ rats. The number of replicating cells was also significantly increased in the ghrelin-treated n0-STZ model. At day 70, n0-STZ rats exhibited hyperglycaemia, despite slight increases in plasma insulin levels. Ghrelin treatment resulted in the improvement of plasma glucose levels, which were associated with normal plasma insulin levels. Pancreatic insulin mRNA and protein levels were significantly increased in ghrelin-treated n0-STZ model animals. CONCLUSIONS/
interpretationThese findings suggest that ghrelin promotes regeneration of beta cells in STZ-treated newborn rats. Thus, early administration of ghrelin may help prevent the development of diabetes in disease-prone subjects after beta cell destruction.
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Registered trials
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