ArticleImmunogenetics2006
HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Review
- Lesion human leukocyte antigen-E is associated with favourable prognosis for patients with oesophageal squamous cell carcinoma.The Journal of international medical research · 2021Article
- The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy.International journal of molecular sciences · 2021Review
- Non-classical human leukocyte antigen class I in Tunisian children with autism.Central-European journal of immunology · 2020Article
- HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after Living-Donor Kidney Transplant.Cells · 2019Article
- Characterisation of major histocompatibility complex class I genes at the fetal-maternal interface of marsupials.Immunogenetics · 2015Article
- Combination of Complement-Dependent Cytotoxicity and Relative Fluorescent Quantification of HLA Length Polymorphisms Facilitates the Detection of a Loss of Heterozygosity.Bone marrow research · 2014Article
- Genetic diversity of the HLA-G coding region in Amerindian populations from the Brazilian Amazon: a possible role of natural selection.Genes and immunity · 2013Article
- HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Recombinant structures expand and contract inter and intragenic diversification at the KIR locus.BMC genomics · 2013Article
- Non-classical MHC-Ι genes in chronic hepatitis B and hepatocellular carcinoma.Immunogenetics · 2012Article
- Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide.Immunogenetics · 2011Article
- Article
- HLA-F complex without peptide binds to MHC class I protein in the open conformer form.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Nomenclature for factors of the HLA system, 2010.Tissue antigens · 2010Review
- The Mhc class II of the Black grouse (Tetrao tetrix) consists of low numbers of B and Y genes with variable diversity and expression.Immunogenetics · 2007Article
- Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E.BMC genetics · 2007Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Despite several studies that defined the polymorphism of the nonclassical human leukocyte antigen-E (HLA-E), HLA-F, and HLA-G genes, most polymorphisms thus far examined in correlative studies were derived from the coding sequences of these genes. In addition, some discrepancies and ambiguities in the available data have persisted in current databases. To expand the data available and to resolve some of the discrepant data, we have defined protocols that allow for the amplification of 6 to 7 kb of contiguous genomic sequence for each gene, including all of the coding and intron sequences, approximately 2 kb of 5' flanking promoter sequence, and 1 kb of 3' flanking sequence. Using long-range polymerase chain reaction (PCR) protocols, generating either one or two PCR products depending on the locus, amplified genomic DNA was directly sequenced to completion using a set of about 30 primers over each locus to yield contiguous sequence data from both strands. Using this approach, we sequenced 33 genomic DNAs, from Asian, African American, and Caucasian samples. The results of this analysis confirmed several previously reported coding sequence variants, identified several new allelic variants, and also defined extensive variation in intron and flanking sequences. It was possible to construct haplotype maps and to identify tagging single nucleotide polymorphisms that can be used to detect the composite variation spanning all three genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.