ArticleAntimicrobial agents and chemotherapy2006
In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections.Pharmaceutics · 2022Review
- Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection.Scientific reports · 2019Article
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- Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection.Drug development and industrial pharmacy · 2017Article
- In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Inhaled anti-infective chemotherapy for respiratory tract infections: successes, challenges and the road ahead.Advanced drug delivery reviews · 2015Review
- Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases.Advanced drug delivery reviews · 2013Review
- New respirable and fast dissolving itraconazole dry powder composition for the treatment of invasive pulmonary aspergillosis.Pharmaceutical research · 2012Article
- Pharmacodynamics of itraconazole against Aspergillus fumigatus in an in vitro model of the human alveolus: perspectives on the treatment of triazole-resistant infection and utility of airway administration.Antimicrobial agents and chemotherapy · 2012Article
- Antibacterial efficacy of inhalable levofloxacin-loaded polymeric nanoparticles against E. coli biofilm cells: the effect of antibiotic release profile.Pharmaceutical research · 2010Article
- Aerosolized Delivery of Antifungal Agents.Current fungal infection reports · 2010Article
- Pulmonary applications and toxicity of engineered nanoparticles.American journal of physiology. Lung cellular and molecular physiology · 2008Review
- Inhaled antimicrobial therapies for respiratory infections.Current infectious disease reports · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.