ArticleAntimicrobial agents and chemotherapy2006
Comparative analysis of chromosome-encoded microcins.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Selective cytotoxicity of microcin H47 against MDA-MB-231 breast cancer cells: an antimicrobial peptide with therapeutic potential.Archives of microbiology · 2026Article
- Antibacterial microcins are ubiquitous and functionally diverse across bacterial communities.Nature communications · 2025Article
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- Semantic search using protein large language models detects class II microcins in bacterial genomes.mSystems · 2024Article
- Secretion of the human parathyroid hormone through a microcin type I secretion system in Escherichia coli.Microbial cell factories · 2024Article
- Semantic search using protein large language models detects class II microcins in bacterial genomes.bioRxiv : the preprint server for biology · 2023Article
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- The "Cins" of Our Fathers: Rejuvenated Interest in Colicins to Combat Drug Resistance.Journal of microbiology (Seoul, Korea) · 2023Review
- Evidence for Widespread Class II Microcins inApplied and environmental microbiology · 2022Article
- Colicins and Microcins Produced byInternational journal of environmental research and public health · 2022Review
- Microcins reveal natural mechanisms of bacterial manipulation to inform therapeutic development.Microbiology (Reading, England) · 2022Article
- Mcc1229, an Stx2a-Amplifying Microcin, Is ProducedInfection and immunity · 2022Article
- Bacteriocins to Thwart Bacterial Resistance in Gram Negative Bacteria.Frontiers in microbiology · 2020Review
- Siderophore-Microcins inFrontiers in cellular and infection microbiology · 2020Review
- Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917.PLoS pathogens · 2019Article
- Microcins inFrontiers in microbiology · 2019Review
- Antimicrobial Susceptibility ofFrontiers in microbiology · 2018Article
- Article
- Bacterial Secretome Analysis in Hunt for Novel Bacteriocins with Ability to ControlIranian journal of biotechnology · 2015Article
- Beyond iron: non-classical biological functions of bacterial siderophores.Dalton transactions (Cambridge, England : 2003) · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microcins are ribosomally synthesized peptide antibiotics that are produced by enterobacterial strains. Although the first studies concentrated on plasmid-encoded activities, in the last years three chromosome-encoded microcins have been described: H47, E492, and M. Here, a new microcin, I47, is presented as a fourth member of this group. Common features exhibited by chromosome-encoded microcins were searched for. The comparison of the genetic clusters responsible for microcin production revealed a preserved general scheme. The clusters essentially comprise a pair of activity-immunity genes which determine antibiotic specificity and a set of microcin maturation and secretion genes which are invariably present and whose protein products are highly homologous among the different producing strains. A strict functional relationship between the maturation and secretion pathways of microcins H47, I47, and E492 was demonstrated through genetic analyses, which included heterologous complementation assays. The peptide precursors of these microcins share a maturation process which implies the addition of a catecholate siderophore of the salmochelin type. Microcins thus acquire the ability to enter gram-negative cells through the catechol receptors. In addition, they employ a common mode of secretion to reach the external milieu by means of a type I export apparatus. The results presented herein lead us to propose that chromosome-encoded microcins constitute a defined subgroup of peptide antibiotics which are strictly related by their modes of synthesis, secretion, and uptake.
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