ArticleAntimicrobial agents and chemotherapy2006
Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.
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175 citing papers in PubMed.
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- Multidrug Resistance andPathogens (Basel, Switzerland) · 2026Article
- Characterization of a novel gene, Lsa(F), conferring resistance to pleuromutilins, lincosamides and streptogramin A in Streptococcus parasuis.Veterinary research · 2026Article
- Genetic diversity and mobile genetic element associated multidrug resistance in Salmonella enterica from broiler chickens in Egypt.Scientific reports · 2026Article
- Phenotypic and genotypic characterization of antimicrobial resistance in coagulase-negative staphylococci from bone lesions in broiler chickens.BMC veterinary research · 2026Article
- Diversity of third-generation cephalosporin-resistant enterobacterales from human and animal samples obtained in Owerri, Nigeria.BMC infectious diseases · 2026Article
- Occurrence of oxazolidinone resistance genes in enterococci, staphylococci, and Mammaliicoccus sciuri from swine slaughterhouse wastewater, Italy.World journal of microbiology & biotechnology · 2026Article
- Epidemiology of Antimicrobial Residues and Phenotypic Resistance of Bacterial Isolates from Waste Milk on California Dairies.Microorganisms · 2026Article
- Frequency of Antimicrobial-Resistant FecalMicroorganisms · 2025Article
- Identification of genetic mutations conferring tedizolid resistance in MRSA mutants.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Detecting antibiotic resistance: classical, molecular, advanced bioengineering, and AI-enhanced approaches.Frontiers in microbiology · 2025Review
- Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Microbiological and Molecular Investigation of Antimicrobial Resistance inAnimals : an open access journal from MDPI · 2024Article
- Characterization of linezolid- and methicillin-resistant coagulase-negative staphylococci in a tertiary hospital in China.BMC infectious diseases · 2024Article
- Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.Pathogens (Basel, Switzerland) · 2024Article
- The burden of antibiotic resistance of the main microorganisms causing infections in humans - review of the literature.Journal of medicine and life · 2024Review
- Impact of florfenicol dosing regimen on the phenotypic and genotypic resistance of enteric bacteria in steers.Scientific reports · 2024Article
- An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.Science (New York, N.Y.) · 2024Article
115 more citing papers are in PubMed but not listed here.
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Abstract
A total of 302 chloramphenicol-resistant Staphylococcus isolates were screened for the presence of the florfenicol/chloramphenicol resistance genes fexA and cfr and their localization on mobile genetic elements. Of the 114 isolates from humans, only a single Staphylococcus aureus isolate showed an elevated MIC to florfenicol, but did not carry either of the known resistance genes, cfr or fexA. In contrast, 11 of the 188 staphylococci from animal sources were considered florfenicol resistant and carried either cfr (one isolate), fexA (five isolates), or both resistance genes (five isolates). In nine cases we confirmed that these genes were carried on a plasmid. Five different types of plasmids could be differentiated on the basis of their sizes, restriction patterns, and resistance genes. The gene fexA, which has previously been shown to be part of the nonconjugative transposon Tn558, was identified in 10 of the 11 resistant isolates from animals. PCR assays were developed to detect different parts of this transposon as well as their physical linkage. Complete copies of Tn558 were found in five different isolates and shown by inverse PCR to be functionally active. Truncated copies of Tn558, in which the tnpA-tnpB area was in part deleted by the integration of a 4,674-bp segment including the gene cfr and a novel 2,446-bp IS21-like insertion sequence, were seen in a plasmid present in three staphylococcal isolates.
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