ArticleInternational immunology2006
Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN.
Article in International immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
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- Metabolic labeling of HIV-1 envelope glycoprotein gp120 to elucidate the effect of gp120 glycosylation on antigen uptake.The Journal of biological chemistry · 2018Article
- Targeting antigens to dendritic cell receptors for vaccine development.Journal of drug delivery · 2013Review
- Quantitative expression of C-type lectin receptors in humans and mice.International journal of molecular sciences · 2012Article
- Dendritic cell-directed lentivector vaccine induces antigen-specific immune responses against murine melanoma.Cancer gene therapy · 2011Article
- New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells.Journal of immunological methods · 2010Article
- HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis.The Journal of experimental medicine · 2009Article
- Toll-like receptor 2 and DC-SIGNR1 differentially regulate suppressors of cytokine signaling 1 in dendritic cells during Mycobacterium tuberculosis infection.The Journal of biological chemistry · 2009Article
- Porcine DC-SIGN: molecular cloning, gene structure, tissue distribution and binding characteristics.Developmental and comparative immunology · 2009Article
- The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement.Blood · 2008Article
- Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells.Chembiochem : a European journal of chemical biology · 2008Article
- Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells.The Journal of experimental medicine · 2007Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CIRE/mDC-SIGN is a C-type lectin we originally identified as a molecule differentially expressed by mouse dendritic cell (DC) populations. Immunostaining with a CIRE/mDC-SIGN-specific mAb revealed that CIRE/mDC-SIGN is indeed on the surface of some CD4+, CD4- 8- DCs and plasmacytoid pre-DCs, but not on CD8+ DCs. It has been proposed that CIRE/mDC-SIGN is the functional orthologue of human DC-SIGN (hDC-SIGN), a molecule that both enhances T cell responses and facilitates antigen uptake. We assessed if CIRE/mDC-SIGN and hDC-SIGN exhibit functional similarities. CIRE/mDC-SIGN is down-regulated upon activation, but unlike hDC-SIGN, incubation with IL-4 and IL-13 did not enhance CIRE/mDC-SIGN expression, indicating differences in gene regulation. Like hDC-SIGN, CIRE/mDC-SIGN bound mannosylated residues. However, we could detect no role for CIRE/mDC-SIGN in T cell-DC interactions and the protein did not bind to pathogens known to interact with hDC-SIGN, including Leishmania mexicana, cytomegalovirus, HIV and lentiviral particles bearing the Ebolavirus glycoprotein. The binding of CIRE/mDC-SIGN to hDC-SIGN ligands was not rescued when CIRE/mDC-SIGN was engineered to express the stalk region of hDC-SIGN. We conclude that there are significant differences in the fine specificity of the C-type lectin domains of hDC-SIGN and CIRE/mDC-SIGN and that these two molecules may not be functional orthologues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.