SynthesisCritical care (London, England)2006
A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis.
Synthesis in Critical care (London, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema.The Cochrane database of systematic reviews · 2019Pooled it
- Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2011Guideline
- Noninvasive ventilation and exercise tolerance in heart failure: A systematic review and meta-analysis.Brazilian journal of physical therapyPooled it
- CPAP for acute cardiogenic pulmonary oedema from out-of-hospital to cardiac intensive care unit: a randomised multicentre study.Intensive care medicine · 2011Trial
- Non-invasive pressure support ventilation and CPAP in cardiogenic pulmonary edema: a multicenter randomized study in the emergency department.Intensive care medicine · 2011Trial
- Impact of CPAP on physical exercise tolerance and sympathetic-vagal balance in patients with chronic heart failure.Brazilian journal of physical therapyTrial
- Obstructive Sleep Apnea in Pregnancy and its Impact on Maternal-Fetal Health: A Hidden Threat - Narrative Review.The open respiratory medicine journal · 2025Review
- The COVID-19 Driving Force: How It Shaped the Evidence of Non-Invasive Respiratory Support.Journal of clinical medicine · 2023Review
- Oxygenation strategy during acute respiratory failure in immunocompromised patients.Journal of intensive medicine · 2021Review
- Treatment of Hypertensive Cardiogenic Edema with Intravenous High-Dose Nitroglycerin in a Patient Presenting with Signs of Respiratory Failure: A Case Report and Review of the Literature.The American journal of case reports · 2019Review
- [Noninvasive ventilation in acute respiratory insufficiency].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Article
- Managing acute pulmonary oedema.Australian prescriber · 2017Review
- Positive airway pressure therapy for heart failure.World journal of cardiology · 2014Review
- [Noninvasive ventilation in out-of-hospital emergency medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014Review
- Review
- Noninvasive ventilation in acute respiratory failure.International journal of chronic obstructive pulmonary disease · 2014Review
- Epidemiology of noninvasive mechanical ventilation in acute respiratory failure--a retrospective population-based study.BMC emergency medicine · 2013Article
- Practical use, effects and complications of prehospital treatment of acute cardiogenic pulmonary edema using the Boussignac CPAP system.International journal of emergency medicine · 2013Article
- End-tidal arterial CO2 partial pressure gradient in patients with severe hypercapnia undergoing noninvasive ventilation.Open access emergency medicine : OAEM · 2013Article
- Management of critically ill patients receiving noninvasive and invasive mechanical ventilation in the emergency department.Open access emergency medicine : OAEM · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe conducted the present study to investigate the potential beneficial and adverse effects of continuous positive airway pressure (CPAP) compared with bi-level positive airway pressure (BiPAP) noninvasive ventilation in patients with cardiogenic pulmonary oedema.
methodWe included randomized controlled studies comparing CPAP and BiPAP treatment in patients with cardiogenic pulmonary oedema from the Cochrane Controlled Trials Register (2005 issue 3), and EMBASE and MEDLINE databases (1966 to 1 December 2005), without language restriction. Two reviewers reviewed the quality of the studies and independently performed data extraction.
resultsSeven randomized controlled studies, including a total of 290 patients with cardiogenic pulmonary oedema, were considered. The hospital mortality (relative risk [RR] 0.76, 95% confidence interval [CI] 0.32-1.78; P = 0.52; I2 = 0%) and risk for requiring invasive ventilation (RR 0.80, 95% CI 0.33-1.94; P = 0.62; I2 = 0%) were not significantly different between patients treated with CPAP and those treated with BiPAP. Stratifying studies that used either fixed or titrated pressure during BiPAP treatment and studies involving patients with or without hypercapnia did not change the results. The duration of noninvasive ventilation required until the pulmonary oedema resolved (weighted mean difference [WMD] in hours = 3.65, 95% CI -12.12 to +19.43; P = 0.65, I2 = 0%) and length of hospital stay (WMD in days = -0.04, 95% CI -2.57 to +2.48; P = 0.97, I2 = 0%) were also not significantly different between the two groups. Based on the limited data available, there was an insignificant trend toward an increase in new onset acute myocardial infarction in patients treated with BiPAP (RR 2.10, 95% CI 0.91-4.84; P = 0.08; I2 = 25.3%).
conclusionBiPAP does not offer any significant clinical benefits over CPAP in patients with acute cardiogenic pulmonary oedema. Until a large randomized controlled trial shows significant clinical benefit and cost-effectiveness of BiPAP versus CPAP in patients with acute cardiogenic pulmonary oedema, the choice of modality will depend mainly on the equipment available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.