ArticleJournal of gastroenterology2006
Significant elevation of serum interleukin-18 levels in patients with acute pancreatitis.
Article in Journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation.The American journal of pathology · 2014Trial
- IL18 Works Like a Two-Side Coin in Acute Pancreatitis.International journal of general medicine · 2026Article
- Review
- Fire in the belly: A scoping review of the immunopathological mechanisms of acute pancreatitis.Frontiers in immunology · 2022Article
- SARS-CoV-2 S Protein Subunit 1 Elicits CaFunction (Oxford, England) · 2022Article
- Eosinophils in the pathogenesis of pancreatic disorders.Seminars in immunopathology · 2021Review
- Acute pancreatic injuries: A complication of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with cytotoxic immunocell activation.Journal of the American Academy of Dermatology · 2021Article
- Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis.International journal of molecular sciences · 2020Review
- Organ Failure Due to Systemic Injury in Acute Pancreatitis.Gastroenterology · 2019Review
- Decreased levels of regulatory B cells in patients with acute pancreatitis: association with the severity of the disease.Oncotarget · 2018Article
- Effect of JAK2/STAT3 signaling pathway on liver injury associated with severe acute pancreatitis in rats.Experimental and therapeutic medicine · 2018Article
- Role of eosinophils in the initiation and progression of pancreatitis pathogenesis.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Pathogenic mechanisms of pancreatitis.World journal of gastrointestinal pharmacology and therapeutics · 2017Review
- Article
- Efficacy of thymosin α1 and interferon α for the treatment of severe acute pancreatitis in a rat model.Molecular medicine reports · 2015Article
- Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation.The American journal of pathology · 2015Article
- Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies.Journal of diabetes research · 2015Review
- Interleukin 18 as an early marker or prognostic factor in acute pancreatitis.Przeglad gastroenterologiczny · 2015Article
- Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis.Cell death & disease · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have reported that peripheral lymphocyte reduction due to apoptosis is linked to the development of subsequent infectious complications in patients with severe acute pancreatitis and that Th1 (helper T cell type 1)/Th2 (helper T cell type 2) balance tends to cause Th1 suppression in experimental severe acute pancreatitis. It has been reported that interleukin (IL)-18 is a cytokine produced from Kupffer cells and activated macrophages, and that IL-18 acts on Th1 cells and in combination with IL-12 strongly induces production of interferon-gamma. However, the role of IL-18 in acute pancreatitis has not yet been fully understood.
methodsSerum IL-18 concentrations were determined by an enzyme-linked immunosorbent assay in 43 patients with acute pancreatitis at the time of admission. The relationships with etiology, pancreatic necrosis, severity, blood biochemical parameters on admission, infection, and organ dysfunction during the clinical course and prognosis were analyzed.
resultsSerum IL-18 levels in patients with acute pancreatitis (656+/- 11pg/ml) were significantly higher than those in healthy volunteers (126+/- pg/ml). Serum IL-18 levels were significantly positively correlated with the Ranson score and Japanese severity score. Among the blood biochemical parameters on admission, base excess and total protein were significantly negatively correlated with serum IL-18 levels. Moreover, the CD4/CD8 rate of lymphocytes, serum IL-6 levels, and serum IL-8 levels were significantly positively correlated with serum IL-18 levels. On day 7 after admission, the CD4/CD8 rate of lymphocytes and the rate of CD4-positive lymphocytes were significantly positively correlated with serum IL-18 levels. Furthermore, serum IL-18 levels in patients with hepatic dysfunction (980+/- 25pg/ml) were significantly higher than those without hepatic dysfunction (464+/- 8pg/ml). Serum IL-18 levels were not related to infection or prognosis. Elevation of serum IL-18 levels continued during 4 weeks after admission.
conclusionsThese results suggest that serum IL-18 levels are significantly elevated and are correlated with severity in patients with acute pancreatitis and that IL-18 may be closely related to helper T cell response and hepatic dysfunction in this disease.
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