ArticleLangenbeck's archives of surgery2006
The vagal nerve as a link between the nervous and immune system in the instance of polymicrobial sepsis.
Article in Langenbeck's archives of surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Clinical influence of vagotomy on postoperative acute phase response.Langenbeck's archives of surgery · 2007Trial
- Reduced preoperative serum choline esterase levels and fecal peritoneal contamination as potential predictors for the leakage of intestinal sutures after source control in secondary peritonitis.World journal of emergency surgery : WJES · 2024Article
- HMGB1: A Potential Target of Nervus Vagus Stimulation in Pediatric SARS-CoV-2-Induced ALI/ARDS.Frontiers in pediatrics · 2022Article
- Increased mortality and altered local immune response in secondary peritonitis after previous visceral operations in mice.Scientific reports · 2021Article
- Hypercapnia attenuates ventilator-induced lung injury through vagus nerve activation.Acta cirurgica brasileira · 2019Article
- Neural pathways involved in infection-induced inflammation: recent insights and clinical implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Selective Activation of Basal Forebrain Cholinergic Neurons Attenuates Polymicrobial Sepsis-Induced Inflammation via the Cholinergic Anti-Inflammatory Pathway.Critical care medicine · 2017Article
- Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNFα in a murine pancreatic cancer model.Oncotarget · 2017Article
- Right Cervical Vagotomy Aggravates Viral Myocarditis in Mice Via the Cholinergic Anti-inflammatory Pathway.Frontiers in pharmacology · 2017Article
- Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.Inflammation · 2014Article
- The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Truncal vagotomy temporarily decreases the pro- and anti-inflammatory cytokine levels in the small intestine.Surgery today · 2014Article
- Upregulating nonneuronal cholinergic activity decreases TNF release from lipopolysaccharide-stimulated RAW264.7 cells.Mediators of inflammation · 2014Article
- Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy.Frontiers in physiology · 2014Review
- Neural reflexes in inflammation and immunity.The Journal of experimental medicine · 2012Review
- Dysfunctional nucleus tractus solitarius: its crucial role in promoting neuropathogenetic cascade of Alzheimer's dementia--a novel hypothesis.Neurochemical research · 2012Review
- The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis.Mediators of inflammation · 2012Article
- Reflex principles of immunological homeostasis.Annual review of immunology · 2012Review
- Immunonutrition with long-chain fatty acids prevents activation of macrophages in the gut wall.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Article
- New concepts of microbial translocation in the neonatal intestine: mechanisms and prevention.Clinics in perinatology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the vagal nerve in the autonomic nervous system is widely well known. Recently, an additional function was revealed serving as a connector between the nervous and immune system. This connection is called the "cholinergic inflammatory pathway." Through stimulation of the acetylcholine receptors located upon the macrophages, the "unspecific" immune system can be directly influenced.
methodsThe vagal nerve was completely transected directly posterior to its passage through the diaphragm. The effect of complete vagotomy was analyzed using a murine model of polymicrobial peritonitis (colon ascendens stent peritonitis, CASP). Survival and clinical course of vagotomized or sham-operated mice were analyzed in the CASP model.
resultsAfter CASP surgery, vagotomy led to a significantly increased mortality (64.7%) in comparison to sham-vagotomized animals (34%). No difference in the bacterial load of various tissues (lung, liver, spleen, blood, lavage fluid, and kidney) from septic animals with or without vagotomy was observed. Vagotomized animals reveal elevated serum cytokine levels (TNF, IL-6, IL-10, and MCP-1) 20 h after the induction of polymicrobial peritonitis.
conclusionThe vagal nerve is therefore an important modulator of the immune system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.