ArticleVirchows Archiv : an international journal of pathology2006
Deregulation of HMGA2 in an aggressive angiomyxoma with t(11;12)(q23;q15).
Article in Virchows Archiv : an international journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 48 citations in OpenAlex.
- A Case Report of Aggressive Angiomyxoma in the Buttock of a Female.Clinical case reports · 2025Article
- Review
- Aggressive Angiomyxoma of the Lower Female Genital Tract: A Review of the MITO Rare Tumors Group.Cancers · 2024Review
- Aggressive Angiomyxoma of the Lower Female Genital Tract in Pregnancy: A Review of the MITO Rare Tumors Group.Cancers · 2023Review
- The contribution of Juan Rosai to the pathology of soft tissue tumors.Pathologica · 2021Review
- Radiomic features from MRI distinguish myxomas from myxofibrosarcomas.BMC medical imaging · 2019Article
- NovelBMJ case reports · 2019Article
- Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Aggressive angiomyxoma of the vulva: a bizarre perineal lesion.Case reports in oncological medicine · 2015Article
- Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature.Cancer genetics and cytogenetics · 2008Review
- Fusion of High Mobility Group AT-hook 2 Gene (Cancer genomics & proteomicsArticle
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggressive angiomyxoma is a soft-tissue neoplasm with a predilection for the pelvic and perineal regions and a tendency to recur locally. Cytogenetic data on this tumor type are limited to five cases, three of which showed rearrangement of chromosomal bands 12q13-15. Molecular investigation of two of the tumors identified the HMGA2 gene as the target of the 12q rearrangements. However, the two previously analyzed tumors were different at the molecular level: in one, the rearrangement of 12q13-15 resulted in a fusion product, whereas, in the second case, the breakpoint was telomeric (3') to the HMGA2, leaving the gene intact although expressed in its entire length. To shed more light on the pathobiology of aggressive angiomyxoma and to investigate the molecular mechanisms behind the involvement of the HMGA2 gene in this tumor type (fusion transcript vs deregulated expression), we investigated, cytogenetically and with molecular techniques, one such tumor which presented a t(11;12)(q23;q15) as the sole karyotypic aberration. FISH analyses demonstrated no structural alteration of HMGA2 at the cytogenetic level; however, expression of the full-length gene was detected molecularly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.