ArticleImmunogenetics2006
Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii).
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Characterisation of major histocompatibility complex class I genes at the fetal-maternal interface of marsupials.Immunogenetics · 2015Article
- Immunome database for marsupials and monotremes.BMC immunology · 2011Article
- MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer.Proceedings. Biological sciences · 2010Article
- MHC-linked and un-linked class I genes in the wallaby.BMC genomics · 2009Article
- Identification of novel major histocompatibility complex class I sequences in a marsupial, the brushtail possum (Trichosurus vulpecula).Immunogenetics · 2008Article
- Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major histocompatibility complex (MHC) plays an essential role in the adaptive immune system of vertebrates through antigen recognition. Although MHC genes are found in all vertebrates, the MHC region is dynamic and has changed throughout vertebrate evolution, making it an important tool for comparative genomics. Marsupials occupy an important position in mammalian phylogeny, yet the MHC of few marsupials has been studied in detail. We report the isolation and analysis of expressed MHC Class I genes from the tammar wallaby, a model marsupial used extensively for the study of mammalian reproduction, genetics, and immunology. We determined that there are at least 11 Class I loci in the tammar genome and isolated six expressed Class I sequences from spleen and testes cDNA libraries, representing at least four loci. Two of the Class I sequences contain substitutions at sites known to be important for antigen binding, perhaps impacting their ability to bind peptides, or the types of peptide to which they bind. Phylogenetic analysis of tammar wallaby Class I sequences and other mammalian Class I sequences suggests that some tammar wallaby and red-necked wallaby loci evolved from common ancestral genes.
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Registered trials
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