Trial reportEuropean journal of nuclear medicine and molecular imaging2006
[18F]FETO for adrenocortical PET imaging: a pilot study in healthy volunteers.
Trial report in European journal of nuclear medicine and molecular imaging, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Advances in the molecular imaging of primary aldosteronism.Annals of nuclear medicine · 2023Review
- Development of [Journal of medicinal chemistry · 2021Article
- Para-chloro-2-[International journal of medical sciences · 2021Article
- Targeted Molecular Imaging in Adrenal Disease-An Emerging Role for Metomidate PET-CT.Diagnostics (Basel, Switzerland) · 2016Review
- Molecular imaging of adrenal neoplasms.Journal of surgical oncology · 2012Review
- Endocrine tumors: the evolving role of positron emission tomography in diagnosis and management.Journal of endocrinological investigation · 2010Review
- Contemporary imaging of incidentally discovered adrenal masses.Nature reviews. Urology · 2009Review
- Imaging and cancer: a review.Molecular oncology · 2008Review
- Something old, something new, PET in adrenal imaging.European journal of nuclear medicine and molecular imaging · 2008Article
- [18F]FETO: metabolic considerations.European journal of nuclear medicine and molecular imaging · 2006Article
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9 authors.
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Abstract
purposeFunctional imaging of the adrenal cortex by means of PET may play an important clinical role. Recently, we presented the synthesis and first evaluation of a novel 11beta-hydroxylase inhibitor, [(18)F]FETO, in rats displaying high tracer accumulation in the adrenals. In this study, we aimed to investigate for the first time the potency of [(18)F]FETO as a PET tracer for the adrenal cortex in humans.
methodsAn average preparation yielded 1-2 GBq of [(18)F]FETO ready to use. Ten healthy volunteers aged 24-57 years (five male and five female) were included in the study. After i.v. administration of 365 MBq [(18)F]FETO (246-391 MBq), dynamic images were acquired in 2D standard mode in 14 frames over 45 min. Afterwards, whole-body scanning was performed. In addition to visual interpretation, semi-quantitative analysis using standardised uptake values (SUVs) was conducted.
results[(18)F]FETO distribution was similar in all scanned volunteers. Visually, pronounced accumulation of [(18)F]FETO was found in the adrenals, whereas moderate uptake was observed-at least in some of the subjects-for liver, renal calices, gallbladder, stomach walls and pancreas. Kidney and bowels showed only faint uptake. Median SUVs for the right and left adrenal glands were 15.6 (10.0-28.6) and 15.7 (10.3-35.9), respectively. The reference tissue (liver) displayed a median SUV of 2.5 (2.2-4.6).
conclusion[(18)F]FETO is a valuable tracer for adrenocortical PET imaging, combining the longer half-life of( 18)F with a high 11beta-hydroxylase selectivity. In accordance with our findings in rats, FETO PET revealed very high accumulation in the adrenal glands in healthy volunteers.
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