ArticleMolecular psychiatry2006
A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 74 citations in OpenAlex.
- Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.Archives of general psychiatry · 2009Trial
- A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders.The pharmacogenomics journal · 2008Trial
- Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.Scientific reports · 2023Article
- Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior.Molecular psychiatry · 2017Article
- SorCS2 is required for BDNF-dependent plasticity in the hippocampus.Molecular psychiatry · 2016Article
- Brain-derived neurotrophic factor protein and mRNA levels in patients with bipolar mania - A preliminary study.Biomedical journal · 2016Article
- Article
- Molecular and genetic basis of depression.Journal of genetics · 2014Review
- Blood levels of brain derived neurotrophic factor in women with bipolar disorder and healthy control women.Journal of affective disorders · 2014Article
- Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.Pharmacogenomics · 2013Article
- Evidence for single nucleotide polymorphisms and their association with bipolar disorder.Neuropsychiatric disease and treatment · 2013Review
- CYP2C9 promoter variable number tandem repeat polymorphism regulates mRNA expression in human livers.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
- BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.Molecular psychiatry · 2012Review
- BDNF polymorphism predicts general intelligence after penetrating traumatic brain injury.PloS one · 2011Article
- Myelin, copper, and the cuprizone model of schizophrenia.Frontiers in bioscience (Scholar edition) · 2011Review
- Population genetic study of the brain-derived neurotrophic factor (BDNF) gene.Molecular psychiatry · 2010Article
- The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009.Neuropsychology review · 2009Review
- Chronic administration of mood stabilizers upregulates BDNF and bcl-2 expression levels in rat frontal cortex.Neurochemical research · 2009Article
- Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.Psychiatric genetics · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have suggested that genetic variations in the brain-derived neurotrophic factor (BDNF) gene may be associated with several neuropsychiatric diseases including bipolar disorder. The present study examined a microsatellite polymorphism located approximately 1.0 kb upstream of the translation initiation site of the BDNF gene for novel sequence variations, association with bipolar disorder, and effects on transcriptional activity. Detailed sequencing analysis revealed that this polymorphism is not a simple dinucleotide repeat, but it is highly polymorphic with a complex structure containing three types of dinucleotide repeats, insertion/deletion, and nucleotide substitutions that gives rise to a total of 23 novel allelic variants. We obtained evidence supporting the association between this polymorphic region (designated as BDNF-linked complex polymorphic region (BDNF-LCPR)) and bipolar disorder. One of the major alleles ('A1' allele) was significantly more common in patients than in controls (odds ratio 2.8, 95% confidential interval 1.5-5.3, P=0.001). Furthermore, a luciferase reporter gene assay in rat primary cultured neurons suggests that this risk allele (A1) has a lower-transcription activity, compared to the other alleles. Our results suggest that the BDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.