ArticleProceedings of the National Academy of Sciences of the United States of America2006
Neutral and adaptive variation in gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers.
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172 citing papers in PubMed, 435 citations in OpenAlex.
- Taxonomic context and genomic architecture jointly shape expression divergence across animals.Evolution; international journal of organic evolution · 2026Article
- Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes.Evolution letters · 2025Article
- Flexibility in Gene Coexpression at Developmental and Evolutionary Timescales.Molecular biology and evolution · 2025Article
- Gene Expression Shifts in Emperor Penguin Adaptation to the Extreme Antarctic Environment.Molecular ecology · 2025Article
- Shallow-water mussels (Mytilus galloprovincialis) adapt to deep-sea environment through transcriptomic and metagenomic insights.Communications biology · 2025Article
- Heat shock protein gene expression varies among populations but does not strongly track recent environmental conditions: implications for biomarker development.Frontiers in physiology · 2025Article
- Comparison of Mitochondrial Genome Expression Differences among Four Skink Species Distributed at Different Latitudes under Low-Temperature Stress.International journal of molecular sciences · 2024Article
- Transcriptomic response to nitrogen availability reveals signatures of adaptive plasticity during tetraploid wheat domestication.The Plant cell · 2024Article
- Evolution is not driven by and toward increasing information and complexity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nascent transcription reveals regulatory changes in extremophile fishes inhabiting hydrogen sulfide-rich environments.Proceedings. Biological sciences · 2024Article
- Gene expression and alternative splicing contribute to adaptive divergence of ecotypes.Heredity · 2024Article
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- A high diversity of non-target site resistance mechanisms to acetolactate-synthase (ALS) inhibiting herbicides has evolved within and among field populations of common ragweed (Ambrosia artemisiifolia L.).BMC plant biology · 2023Article
- Evolutionary Analyses of Gene Expression Divergence in Panicum hallii: Exploring Constitutive and Plastic Responses Using Reciprocal Transplants.Molecular biology and evolution · 2023Article
- Impact of the acquired subgenome on the transcriptional landscape in Brettanomyces bruxellensis allopolyploids.G3 (Bethesda, Md.) · 2023Article
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- Population transcriptomics uncover the relative roles of positive selection and differential expression in Batrachium bungei adaptation to the Qinghai-Tibetan plateau.Plant cell reports · 2023Article
- Extensive Adaptive Variation in Gene Expression within and between Closely Related Horseshoe Bats (Chiroptera,Animals : an open access journal from MDPI · 2022Article
- Expression plasticity regulates intraspecific variation in the acclimatization potential of a reef-building coral.Nature communications · 2022Article
112 more citing papers are in PubMed but not listed here.
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2 authors at 2 institutions in 1 country.
Funding
Abstract
Variation among populations in gene expression should be related to the accumulation of random-neutral changes and evolution by natural selection. The following evolutionary analysis has general applicability to biological and medical science because it accounts for genetic relatedness and identifies patterns of expression variation that are affected by natural selection. To identify genes evolving by natural selection, we allocate the maximum among-population variation to genetic distance and then examine the remaining variation relative to a hypothesized important ecological parameter (temperature). These analyses measure the expression of metabolic genes in common-gardened populations of the fish Fundulus heteroclitus whose habitat is distributed along a steep thermal gradient. Although much of the variation in gene expression fits a null model of neutral drift, the variation in expression for 22% of the genes that regress with habitat temperature was far greater than could be accounted for by genetic distance alone. The most parsimonious explanation for among-population variation for these genes is evolution by natural selection. In addition, many metabolic genes have patterns of variation incongruent with neutral evolution: They have too much or too little variation. These patterns of biological variation in expression may reflect important physiological or ecological functions.
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