ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2006
Molecular regulation of apoptosis in fast plantaris muscles of aged rats.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 66 citations in OpenAlex.
- Age-Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia.Cells · 2023Review
- MBNL1-Associated Mitochondrial Dysfunction and Apoptosis in C2C12 Myotubes and Mouse Skeletal Muscle.International journal of molecular sciences · 2020Article
- The Effects of Calcium-Oxidative medicine and cellular longevity · 2020Article
- mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.Aging cell · 2019Article
- Effects of hindlimb suspension and reloading on gastrocnemius and soleus muscle mass and function in geriatric mice.Experimental gerontology · 2019Article
- Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats.Experimental gerontology · 2017Article
- Article
- Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities.Aging cell · 2015Article
- Green tea extract attenuates muscle loss and improves muscle function during disuse, but fails to improve muscle recovery following unloading in aged rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Non-weight bearing-induced muscle weakness: the role of myosin quantity and quality in MHC type II fibers.American journal of physiology. Cell physiology · 2014Article
- Epigallocatechin-3-gallate improves plantaris muscle recovery after disuse in aged rats.Experimental gerontology · 2014Article
- Regulation of satellite cell function in sarcopenia.Frontiers in aging neuroscience · 2014Review
- Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice.Age (Dordrecht, Netherlands) · 2013Article
- Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials.The international journal of biochemistry & cell biology · 2013Review
- Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.Biological chemistry · 2013Review
- Genes, tolerance and systemic autoimmunity.Autoimmunity reviews · 2012Review
- Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy.PloS one · 2012Article
- The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair.International journal of biological sciences · 2012Review
- β-Hydroxy-β-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This study tested the hypothesis that aging exacerbates apoptotic signaling in rat fast plantaris muscle during muscle unloading. Plantaris muscle mass was 22% lower in aged animals and the apoptotic index was 600% higher, when compared to those in young adult animals. Following 14 days of hind-limb unloading, absolute plantaris muscle mass was 20% lower in young adult animals with a corresponding 200% higher elevation of the apoptotic index. Unloading had no affect on muscle weight or apoptotic index of aged plantaris muscles. The changes in pro-apoptotic messenger RNA (mRNA) for apoptotic protease activating factor-1 (Apaf-1), Bax, and inhibitor of differentiation protein-2 (Id2) were exacerbated with aging. Bax and Bcl-2 protein levels were also altered differently in aged muscle, compared to young. Significant positive correlations were observed between the changes in Id2 and Bax mRNA, and Id2 and caspase-9 mRNA. These data suggest that a pro-apoptotic environment may contribute to aging-associated atrophy in fast skeletal muscle, but apoptotic signaling differs by age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.