ArticleBMC structural biology2006
Structural proteomics of minimal organisms: conservation of protein fold usage and evolutionary implications.
Article in BMC structural biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- The comprehensive microbial resource.Nucleic acids research · 2010Article
- FINDSITE: a combined evolution/structure-based approach to protein function prediction.Briefings in bioinformatics · 2009Review
- Reductive evolution of architectural repertoires in proteomes and the birth of the tripartite world.Genome research · 2007Article
- Structure-based inference of molecular functions of proteins of unknown function from Berkeley Structural Genomics Center.Journal of structural and functional genomics · 2007Review
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2 authors at 1 institution in 1 country.
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Abstract
backgroundDetermining the complete repertoire of protein structures for all soluble, globular proteins in a single organism has been one of the major goals of several structural genomics projects in recent years.
resultsWe report that this goal has nearly been reached for several "minimal organisms"--parasites or symbionts with reduced genomes--for which over 95% of the soluble, globular proteins may now be assigned folds, overall 3-D backbone structures. We analyze the structures of these proteins as they relate to cellular functions, and compare conservation of fold usage between functional categories. We also compare patterns in the conservation of folds among minimal organisms and those observed between minimal organisms and other bacteria.
conclusionWe find that proteins performing essential cellular functions closely related to transcription and translation exhibit a higher degree of conservation in fold usage than proteins in other functional categories. Folds related to transcription and translation functional categories were also overrepresented in minimal organisms compared to other bacteria.
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