Evidence map›Paper›PMID 16565821›Full record

ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2006

Anti-inflammatory agents in the management of alimentary mucositis.

Rajesh V Lalla, Mark M Schubert, Rene-Jean Bensadoun, Dorothy Keefe

Abstract readReview
PubMed Publisher
In one paragraph

Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Pooled it
  2. Clinical relevance of the use of DentoxolWorld journal of clinical oncology · 2022
    Trial
  3. Trial
  4. A randomized, double-blind, placebo-controlled trial of misoprostol for oral mucositis secondary to high-dose chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012
    Trial
  5. An Inulin-Type Fructan CP-A fromPharmaceuticals (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Mucoadhesive formulation ofToxicology reports · 2015
    Article
  11. The MASCC/ISOO Mucositis Guidelines Update: introduction to the first set of articles.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Article
  12. Article
  13. Article
  14. Article
  15. Radiation induced oral mucositis.Indian journal of palliative care · 2009
    Article
  16. Management of oral mucositis in patients who have cancer.Dental clinics of North America · 2008
    Review
  17. New pathways for alimentary mucositis.Journal of oncology · 2008
    Article
  18. Mucositis guidelines: what have they achieved, and where to from here?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2006
    Review
  19. Developing evidence-based guidelines for management of alimentary mucositis: process and pitfalls.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2006
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Rajesh V LallaDepartment of Oral Health and Diagnostic Sciences MC1605, University of Connecticut Health Center, 263, Farmington Avenue, Farmington, 06030-1605, USA. lalla@nso2.uchc.edu
Mark M Schubert
Rene-Jean Bensadoun
Dorothy Keefe
Centre Antoine Lacassagne · FRUConn Health · USUniversity of Adelaide · AUUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlimentary mucositis is a significant complication of cancer therapy, with important clinical and economic implications. MATERIALS AND

methodsIn June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology conducted an evidence-based review of the literature on alimentary mucositis. The goal of this literature review was to update previously published guidelines for the management of mucositis.

resultsThis article reports the findings of the subgroup charged with reviewing the literature related to anti-inflammatory interventions. Considerable preclinical and clinical evidence suggests that the use of anti-inflammatory agents may be a promising approach to reduce the severity of mucositis. However, there was not enough evidence to support any new guidelines advocating the use of any specific anti-inflammatory intervention.

conclusionThus, there is a need for well-designed clinical trials evaluating the use of anti-inflammatory agents in the management of mucositis.

Indexed as

NeoplasmsAllopurinolAnimalsAnti-Inflammatory AgentsAntineoplastic AgentsAnti-Ulcer AgentsBenzydamineClinical Trials as TopicDrug EvaluationEvidence-Based MedicineFlurbiprofenGastrointestinal DiseasesHealth Services Needs and DemandHumansMetalloproteinsMisoprostolAllopurinolAnti-Inflammatory AgentsAntineoplastic AgentsAnti-Ulcer AgentsBenzydamineFlurbiprofenirsogladineMetalloproteinsMisoprostolorgoteinRadiation-Protective AgentsTriazines

Identifiers

PMID16565821
OpenAlexW1968960139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.