ReviewMarine biotechnology (New York, N.Y.)
Antiplasmodial marine natural products in the perspective of current chemotherapy and prevention of malaria: a review.
Review in Marine biotechnology (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Antiplasmodial potential of phytochemicals from Citrus aurantifolia peels: a comprehensive in vitro and in silico study.BMC chemistry · 2024Article
- Marine Terpenic Endoperoxides.Marine drugs · 2021Review
- Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids.Molecules (Basel, Switzerland) · 2021Review
- Preparation, COX-2 Inhibition and Anticancer Activity of Sclerotiorin Derivatives.Marine drugs · 2020Article
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
- Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products.Chemical reviews · 2016Review
- Syntheses and biological studies of marine terpenoids derived from inorganic cyanide.Natural product reports · 2015Review
- Antimalarial activity of axidjiferosides, new β-galactosylceramides from the African sponge Axinyssa djiferi.Marine drugs · 2013Article
- Anti-amoebic properties of a Malaysian marine sponge Aaptos sp. on Acanthamoeba castellanii.World journal of microbiology & biotechnology · 2012Article
- Antiplasmodial activities of homogentisic acid derivative protein kinase inhibitors isolated from a Vanuatu marine sponge Pseudoceratina sp.Marine drugs · 2009Article
- Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.Biochimica et biophysica acta · 2009Review
- Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.Journal of natural products · 2009Article
- Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.Journal of natural products · 2009Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The difficulty of obtaining an antimalarial vaccine along traditional lines, because of the highly adaptive character of the malaria parasite, prompts a ceaseless need for new drugs. To this end, marine organisms have been explored recently, as reviewed in this article within the perspective of clinically available antimalarial drugs and promising candidates. Most promising are tetrahydropyrrolo[1,2-alpha]pyrimidinium, bis-indole, and C(11)-N(5) alkaloids from sponges; pyridoacridone and decahydroquinoline alkaloids from ascidians; and pyrrole alkaloids from fungi, as well as polycyclic polyketides, norditerpene, and polyketide endoperoxides, terpene isonitriles, and, particularly, mixed-biogenesis alpha-galactosyl ceramides from sponges. The first and the latter classes of agents best fulfill the requirements for combinatorial synthesis in providing a wide variety of compounds for high-throughput screening and toxicity tests. These results came largely from nonprofit organizations, a trend that we foresee will continue. However, partnership with the pharmaceutical industry was and is needed to bring candidate drugs to the clinic. In any event, success will not be achieved without political plans to make the results of technology easily available to poor populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.