ReviewProceedings of the American Thoracic Society2006
Immunoregulatory and antimicrobial effects of nitrogen oxides.
Review in Proceedings of the American Thoracic Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Breath-by-breath quantification of inhaled nitric oxide absorption and modeling of methemoglobin kinetics.Redox biology · 2026Article
- The Potential Role of Nitric Oxide as a Therapeutic Agent against SARS-CoV-2 Infection.International journal of molecular sciences · 2023Review
- Critical role of nitric oxide in impeding COVID-19 transmission and prevention: a promising possibility.Environmental science and pollution research international · 2022Review
- Roles ofPreventive nutrition and food science · 2021Article
- Evaluation of an Anti-Thrombotic Continuous Lactate and Blood Pressure Monitoring Catheter in an In Vivo Piglet Model undergoing Open-Heart Surgery with Cardiopulmonary Bypass.Chemosensors (Basel, Switzerland) · 2020Article
- Cytonemes Versus Neutrophil Extracellular Traps in the Fight of Neutrophils with Microbes.International journal of molecular sciences · 2020Review
- Evaluation of Continuous Lactate Monitoring Systems within a Heparinized In Vivo Porcine Model Intravenously and Subcutaneously.Biosensors · 2018Article
- Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide.International forum of allergy & rhinology · 2017Article
- Role of Inhaled Nitric Oxide in the Management of Severe Acute Respiratory Distress Syndrome.Frontiers in pediatrics · 2016Review
- Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis.Science translational medicine · 2014Article
- Nitric oxide-flux dependent bacterial adhesion and viability at fibrinogen-coated surfaces.Biomaterials science · 2013Article
- Examination of bacterial resistance to exogenous nitric oxide.Nitric oxide : biology and chemistry · 2012Article
- Immunostimulation in the era of the metagenome.Cellular & molecular immunology · 2011Review
- Synergy of nitric oxide and silver sulfadiazine against gram-negative, gram-positive, and antibiotic-resistant pathogens.Molecular pharmaceutics · 2010Article
- The multiple actions of NO.Pflugers Archiv : European journal of physiology · 2010Review
- Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination.Expert review of neurotherapeutics · 2010Review
- Antimicrobial activity of the iron-sulfur nitroso compound Roussin's black salt [Fe4S3(NO)7] on the hyperthermophilic archaeon Pyrococcus furiosus.Applied and environmental microbiology · 2009Article
- Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2008Review
- S-nitrosothiol-modified dendrimers as nitric oxide delivery vehicles.Biomacromolecules · 2008Article
- Manipulation of nitric oxide in an animal model of acute liver injury. The impact on liver and intestinal function.The Libyan journal of medicine · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The therapeutic effects of inhaled nitric oxide (NO) therapy are thought to be restricted to the pulmonary vasculature because of rapid inactivation of NO by hemoglobin in the bloodstream. However, recent data suggest that inhaled NO may not only be scavenged by the heme iron of hemoglobin but also may react with protein thiols in the bloodstream, including cysteine-93 of the hemoglobin B subunit. Reaction of NO with protein or peptide thiols is termed S-nitrosylation and results in the formation of relatively stable protein S-nitrosothiols that carry NO bioactivity to distal organs. Thus, inhaled NO-induced protein S-nitrosylation may allow inhaled NO to have multiple as yet undiscovered physiologic and pathophysiologic effects outside of the lung. Here we review the immunoregulatory and antimicrobial functions of NO and the potential effects of inhaled NO therapy on host defense.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.