ArticleProceedings of the National Academy of Sciences of the United States of America2006
Controlling methicillin-resistant Staphylococcus aureus: quantifying the effects of interventions and rapid diagnostic testing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Simulation models for transmission of health care-associated infection: A systematic review.American journal of infection control · 2020Pooled it
- Population-level mathematical modeling of antimicrobial resistance: a systematic review.BMC medicine · 2019Pooled it
- Impact of mupirocin resistance on the transmission and control of healthcare-associated MRSA.The Journal of antimicrobial chemotherapy · 2015Pooled it
- Modelling the transmission of healthcare associated infections: a systematic review.BMC infectious diseases · 2013Pooled it
- Trial
- Intervention to reduce transmission of resistant bacteria in intensive care.The New England journal of medicine · 2011Trial
- Transmission thresholds for the spread of infections in healthcare facilities.PLoS computational biology · 2025Article
- System identifiability in a time-evolving agent-based model.PloS one · 2024Article
- Ensemble inference of unobserved infections in networks using partial observations.PLoS computational biology · 2023Article
- Challenges in Forecasting Antimicrobial Resistance.Emerging infectious diseases · 2023Review
- Exploring the Barriers in the Uptake of the Dutch MRSA 'Search and Destroy' Policy Using the Cascade of Care Approach.Antibiotics (Basel, Switzerland) · 2022Article
- Pillars for prevention and control of healthcare-associated infections: an Italian expert opinion statement.Antimicrobial resistance and infection control · 2022Review
- Identifying asymptomatic spreaders of antimicrobial-resistant pathogens in hospital settings.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Nitrogen Functionalities of Amino-Functionalized Nitrogen-Doped Graphene Quantum Dots for Highly Efficient Enhancement of Antimicrobial Therapy to Eliminate Methicillin-ResistantInternational journal of molecular sciences · 2021Article
- Screening for multi-drug-resistant Gram-negative bacteria: what is effective and justifiable?Monash bioethics review · 2020Article
- Strategies to Prevent Healthcare-Associated Infections: A Narrative Overview.Risk management and healthcare policy · 2020Review
- Quantifying the transmission dynamics of MRSA in the community and healthcare settings in a low-prevalence country.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Perfect counterfactuals for epidemic simulations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation.PLoS biology · 2019Article
- Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control of nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) has been unsuccessful in most countries. Yet, some countries have maintained low endemic levels by implementing nationwide MRSA-specific infection control measures, such as "search & destroy" (S&D). These strategies, however, are not based on well designed studies, and their use in countries with high levels of endemicity is controversial. We present a stochastic three-hospital model and an analytical one-hospital model to quantify the effectiveness of different infection control measures and to predict the effects of rapid diagnostic testing (RDT) on isolation needs. Isolation of MRSA carriers identified by clinical cultures is insufficient to control MRSA. However, combined with proactive search (of high-risk patients on admission and/or contacts of index patients), it will maintain prevalence levels <1%. Concerted implementation of S&D in countries with high nosocomial endemicity reduces nosocomial prevalence to <1% within 6 years. Stepwise implementation of control measures can reduce isolation capacities needed. RDT can reduce isolation needs by >90% in low-endemic settings and by 20% in high-endemic settings. Surveillance of colonization and improved hand hygiene can markedly increase control efficacy. These findings strongly suggest that: (i) causality exists between S&D and low MRSA prevalence; (ii) isolating MRSA carriers identified by clinical cultures as a single measure is insufficient for control; (iii) a combined approach of isolation and screening confers efficacy; and (iv) MRSA-prevalence levels can be reduced to <1% in high-endemic settings by S&D or a stepwise approach to interventions. RDT can markedly enhance feasibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.