ArticleBiophysical journal2006
An anion antiporter model of prestin, the outer hair cell motor protein.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- Folding of prestin's anion-binding site and the mechanism of outer hair cell electromotility.eLife · 2023Article
- Article
- A novel theoretical framework reveals more than one voltage-sensing pathway in the lateral membrane of outer hair cells.The Journal of general physiology · 2020Article
- Importance of SLC26 Transmembrane Anion Exchangers in Sperm Post-testicular Maturation and Fertilization Potential.Frontiers in cell and developmental biology · 2019Review
- Membrane prestin expression correlates with the magnitude of prestin-associated charge movement.Hearing research · 2016Article
- The potential and electric field in the cochlear outer hair cell membrane.Medical & biological engineering & computing · 2015Article
- A model of ionic transport and osmotic volume control in cochlear outer hair cells.Interface focus · 2014Article
- Anion translocation through an Slc26 transporter mediates lumen expansion during tubulogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Pixels as ROIs (PAR): a less-biased and statistically powerful approach for gleaning functional information from image stacks.PloS one · 2013Article
- Article
- Mammalian prestin is a weak Cl⁻/HCO₃⁻ electrogenic antiporter.The Journal of physiology · 2012Article
- Anion transport by the cochlear motor protein prestin.The Journal of physiology · 2012Article
- Effect of membrane mechanics on charge transfer by the membrane protein prestin.Biomechanics and modeling in mechanobiology · 2012Article
- Engineered pendrin protein, an anion transporter and molecular motor.The Journal of biological chemistry · 2011Article
- A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.The EMBO journal · 2011Article
- Membrane thickness sensitivity of prestin orthologs: the evolution of a piezoelectric protein.Biophysical journal · 2011Article
- Prestin and the cholinergic receptor of hair cells: positively-selected proteins in mammals.Hearing research · 2011Review
- Evidence that prestin has at least two voltage-dependent steps.The Journal of biological chemistry · 2011Article
- From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cochlear amplification in mammalian hearing relies on an active mechanical feedback process generated by outer hair cells, driven by a protein, prestin (SLC26A5), in the lateral membrane. We have used kinetic models to understand the mechanism by which prestin might function. We show that the two previous hypotheses of prestin, which assume prestin cannot operate as a transporter, are insufficient to explain previously published data. We propose an alternative model of prestin as an electrogenic anion exchanger, exchanging one Cl(-) ion for one divalent or two monovalent anions. This model can reproduce the key aspects of previous experimental observations. The experimentally observed charge movements are produced by the translocation of one Cl(-) ion combined with intrinsic positively charged residues, while the transport of the counteranion is electroneutral. We tested the model with measurements of the Cl(-) dependence of charge movement, using SO(4)(2-) to replace Cl(-). The data was compatible with the predictions of the model, suggesting that prestin does indeed function as a transporter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.