ArticleProceedings of the National Academy of Sciences of the United States of America1991
Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Syntaxin 1A supports voltage-dependent inhibition of alpha1B Ca2+ channels by Gbetagamma in chick sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Gating of single N-type calcium channels recorded from bullfrog sympathetic neurons.The Journal of general physiology · 1999Article
- Metabolism and trafficking of N-type voltage-operated calcium channels in neurosecretory cells.Journal of bioenergetics and biomembranes · 1998Review
- Inhibition of N- and P/Q-type calcium channels by postsynaptic GABAB receptor activation in rat supraoptic neurones.The Journal of physiology · 1998Article
- Decay of prepulse facilitation of N type calcium channels during G protein inhibition is consistent with binding of a single Gbeta subunit.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors.The Journal of physiology · 1998Article
- The Ca2+ channel beta3 subunit differentially modulates G-protein sensitivity of alpha1A and alpha1B Ca2+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- cAMP-dependent enhancement of dihydropyridine-sensitive calcium channel availability in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Facilitation of N-type calcium current is dependent on the frequency of action potential-like depolarizations in dissociated cholinergic basal forebrain neurons of the guinea pig.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Multiple components of Ca2+ channel facilitation in cerebellar granule cells: expression of facilitation during development in culture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- ATP and G proteins affect the runup of the Ca2+ current in bovine chromaffin cells.Pflugers Archiv : European journal of physiology · 1995Article
- Phosphorylation- and voltage-dependent inhibition of neuronal calcium currents by activation of human D2(short) dopamine receptors.British journal of pharmacology · 1995Article
- Voltage-dependent facilitation of a neuronal alpha 1C L-type calcium channel.The EMBO journal · 1994Article
- Selective potentiation of a novel calcium channel in rat hippocampal neurones.The Journal of physiology · 1994Article
- Double-pulse facilitation of smooth muscle alpha 1-subunit Ca2+ channels expressed in CHO cells.The EMBO journal · 1994Article
- G-protein activation mediates prepulse facilitation of Ca2+ channel currents in bovine chromaffin cells.The Journal of membrane biology · 1994Article
- Tonic inhibition of neuronal calcium channels by G proteins removed during whole-cell patch-clamp experiments.Pflugers Archiv : European journal of physiology · 1994Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A significant fraction of differentiated NG108-15 neuroblastoma/glioma cells have Ca2+ channel current different from that of undifferentiated cells. In the former cells, the Ca2+ channel sensitive to omega-conotoxin GVIA had slowed activation kinetics and was facilitated by depolarizing prepulses. These kinetic features are identical to those produced by inhibition of the channel by G proteins. Prolonged treatment with prostaglandin E1 and theophylline, agents that cause cellular differentiation, promoted incidence and extent of the tonic inhibition. Intracellular guanosine 5'-[beta-thio]diphosphate removed the tonic inhibition, suggesting sustained activation of a G protein, but pertussis toxin did not block it. A sulfhydryl alkylating agent, N-ethylmaleimide (0.1 mM), rapidly eliminated agonist-induced inhibition, whereas N-ethylmaleimide spared the tonic inhibition and the one induced by intracellular guanosine 5'-[gamma-thio]triphosphate. An agonist could further inhibit the Ca2+ channel that was already tonically inhibited. After washout of an inhibitory agonist, the tonic inhibition was temporarily removed. This "rebound facilitation" gradually faded within a few minutes. Pertussis toxin or N-ethylmaleimide prevented the rebound facilitation, whereas phorbol ester, forskolin, or arachidonic acid induced neither the rebound facilitation nor the tonic inhibition. Whatever its mechanism, the tonic inhibition of Ca2+ channels may serve as the basis for long-term and bidirectional regulation of activity of neuronal Ca2+ channels.
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