ArticleNucleic acids research1991
Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Multimodal Therapy Approaches for NUT Carcinoma by Dual Combination of Oncolytic VirusViruses · 2024Article
- Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages.The EMBO journal · 2023Article
- Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice.Journal of virology · 2012Article
- Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice.The Journal of clinical investigation · 2008Article
- Activation of c-Jun N-terminal kinase (JNK) pathway by HSV-1 immediate early protein ICP0.Experimental cell research · 2005Article
- Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells.Gene therapy · 2003Article
- Requirements for the induction of interleukin-6 by herpes simplex virus-infected leukocytes.Journal of virology · 2001Article
- Molecular pathways in virus-induced cytokine production.Microbiology and molecular biology reviews : MMBR · 2001Review
- Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth.Journal of virology · 2000Article
- Activation of cJUN N-terminal kinase by herpes simplex virus type 1 enhances viral replication.Journal of virology · 1999Article
- Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures.Journal of virology · 1997Article
- The latency-related gene of bovine herpesvirus 1 encodes a product which inhibits cell cycle progression.Journal of virology · 1996Article
- Stress and reactivation of latent herpes simplex virus: a fusion of behavioral medicine and molecular biology.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 1995Article
- Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function.Journal of virology · 1994Article
- Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.The Journal of experimental medicine · 1994Article
- Multimerization of ICP0, a herpes simplex virus immediate-early protein.Journal of virology · 1992Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lytic infection with herpes simplex virus (HSV) results in the repression of most host cell protein synthesis but produces an increased activity of the cellular AP-1 transcription factor. This increase is paralleled by an increase in the transcription rate of the proto-oncogene encoding the AP-1 component, c-Jun resulting in an increase in c-Jun protein in infected cells. The increased AP-1 activity in infected cells is dependent upon the HSV immediate-early protein ICPO. Thus a mutant lacking the gene encoding this protein fails to increase AP-1 activity whilst an ICPO expression plasmid can specifically increase the activity of an AP-1 dependent promoter in co-transfection experiments. The implications of these effects in the interaction of HSV with cultured cells are discussed.
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