ReviewJournal of cellular and molecular medicine
Morphological aspects of apoptosis in heart diseases.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 98 citations in OpenAlex.
- FERPIR promotes cardiomyocyte survival and attenuates cardiac remodeling after myocardial infarction.Cell death & disease · 2026Article
- Ryanodine Receptor Staining Identifies Viable Cardiomyocytes in Human and Rabbit Cardiac Tissue Slices.International journal of molecular sciences · 2023Article
- miR-431-5p regulates apoptosis of cardiomyocytes after acute myocardial infarction via targeting selenoprotein T.Physiological research · 2022Article
- Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress.Scientific reports · 2019Article
- The Role of Autophagy in Acute Myocardial Infarction.Frontiers in pharmacology · 2019Review
- Deduction of novel genes potentially involved in hypoxic AC16 human cardiomyocytes using next-generation sequencing and bioinformatics approaches.International journal of molecular medicine · 2018Article
- Anti-apoptosis in nonmyocytes and pro-autophagy in cardiomyocytes: two strategies against postinfarction heart failure through regulation of cell death/degeneration.Heart failure reviews · 2018Review
- Potential mechanisms responsible for cardioprotective effects of sodium-glucose co-transporter 2 inhibitors.Cardiovascular diabetology · 2018Review
- Early markers of myocardial ischemia: from the experimental model to forensic pathology cases of sudden cardiac death.International journal of legal medicine · 2018Observational
- Regioselective Synthesis of a Family of β-Lactams Bearing a Triazole Moiety as Potential Apoptosis Inhibitors.ChemistryOpen · 2016Article
- Early markers for myocardial ischemia and sudden cardiac death.International journal of legal medicine · 2016Article
- Recombinant adeno-associated virus serotype 9 with p65 ribozyme protects H9c2 cells from oxidative stress through inhibiting NF-κB signaling pathway.Journal of geriatric cardiology : JGC · 2014Article
- Mitochondria play a central role in nonischemic cardiomyocyte necrosis: common to acute and chronic stressor states.Pflugers Archiv : European journal of physiology · 2012Review
- In situ ligation: a decade and a half of experience.Methods in molecular biology (Clifton, N.J.) · 2011Review
- Biomimetic matrices for myocardial stabilization and stem cell transplantation.Journal of biomedical materials research. Part A · 2010Article
- Molecular pathogenetic mechanisms and new therapeutic perspectives in anthracycline-induced cardiomyopathy.Italian journal of pediatrics · 2009Article
- Apoptosis predominates in nonmyocytes in heart failure.American journal of physiology. Heart and circulatory physiology · 2009Article
- Myocardial survival signaling in response to stem cell transplantation.Journal of the American College of Surgeons · 2009Article
- The magnitude and temporal dependence of apoptosis early after myocardial ischemia with or without reperfusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Contractility in health and disease.Journal of cellular and molecular medicine · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that apoptosis may be responsible for a significant amount of cardiomyocyte death during acute myocardial infarction as well as for a progressive loss of surviving cells in failing hearts. Typical apoptosis can indeed be induced in cardiomyocytes at the experimental conditions. In actual heart diseases, in contrast, there is very little direct morphological evidence of apoptosis in cardiomyocytes occurring at any stage of myocardial infarction and heart failure, despite the availability of much indirect evidence that includes detection of DNA fragmentation and apoptosis-related factors. For that reason, the potential efficacy of therapeutic intervention to prevent apoptosis remains controversial. This review will survey available data from both animals and humans to critically assess the role of cardiomyocyte apoptosis during myocardial infarction and its relevance to myocardial remodeling and during progression to heart failure. Also considered will be nonmyocyte interstitial cells, which have received less attention than myocytes despite definitive evidence of their apoptosis in the infarcted heart and recent studies suggesting that blockade of apoptosis among these cells mitigates postinfarction cardiac remodeling and heart failure. We conclude from our survey that there are many hurdles to surmount before regulation of apoptosis can be clinically applied in the treatment of myocardial infarction and heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.