ArticleBreast cancer research : BCR2006
Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer.
Article in Breast cancer research : BCR, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis.Scientific reports · 2021Pooled it
- Genome-wide association study of germline variants and breast cancer-specific mortality.British journal of cancer · 2019Pooled it
- Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.Cancer biology & therapy · 2017Trial
- Genetic insights into the timing of metastasis: a secondary analysis of the Count Me In metastatic breast cancer cohort.Frontiers in cell and developmental biology · 2026Article
- Impact ofCancers · 2024Article
- The role of SIPA1 in the development of cancer and metastases (Review).Molecular and clinical oncology · 2020Review
- A scan for genes associated with cancer mortality and longevity in pedigree dog breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray.Biomolecules · 2019Article
- Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation.Neoplasia (New York, N.Y.) · 2018Article
- Genetic insights into the morass of metastatic heterogeneity.Nature reviews. Cancer · 2018Review
- Single nucleotide variants in metastasis-related genes are associated with breast cancer risk, by lymph node involvement and estrogen receptor status, in women with European and African ancestry.Molecular carcinogenesis · 2017Article
- An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.PLoS genetics · 2016Article
- Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc.Oncotarget · 2015Article
- The role of individual inheritance in tumor progression and metastasis.Journal of molecular medicine (Berlin, Germany) · 2015Review
- Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells.Oncogene · 2015Article
- The SIPA1 -313A>G polymorphism is associated with prognosis in inoperable non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- High SIPA-1 expression in proximal tubules of human kidneys under pathological conditions.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015Article
- [Identification analysis of eukaryotic expression plasmid Rap2a and its effect on the migration of lung cancer cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2014Article
- Melanoma metastasis: new concepts and evolving paradigms.Oncogene · 2014Review
- Understanding susceptibility to breast cancer metastasis: the genetic approach.Breast cancer management · 2014Article
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6 authors at 3 institutions in 1 country.
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Abstract
introductionThere is growing evidence that heritable genetic variation modulates metastatic efficiency. Our previous work using a mouse mammary tumor model has shown that metastatic efficiency is modulated by the GTPase-activating protein encoded by Sipa1 ('signal-induced proliferation-associated gene 1'). The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) within the human SIPA1 gene are associated with metastasis and other disease characteristics in breast cancer.
methodThe study population (n = 300) consisted of randomly selected non-Hispanic Caucasian breast cancer patients identified from a larger population-based series. Genomic DNA was extracted from peripheral leukocytes. Three previously described SNPs within SIPA1 (one within the promoter [-313G>A] and two exonic [545C>T and 2760G>A]) were characterized using SNP-specific PCR.
resultsThe variant 2760G>A and the -313G>A allele were associated with lymph node involvement (P = 0.0062 and P = 0.0083, respectively), and the variant 545C>T was associated with estrogen receptor negative tumors (P = 0.0012) and with progesterone negative tumors (P = 0.0339). Associations were identified between haplotypes defined by the three SNPs and disease progression. Haplotype 3 defined by variants -313G>A and 2760G>A was associated with positive lymph node involvement (P = 0.0051), and haplotype 4 defined by variant 545C>T was associated with estrogen receptor and progesterone receptor negative status (P = 0.0053 and P = 0.0199, respectively).
conclusionOur findings imply that SIPA1 germline polymorphisms are associated with aggressive disease behavior in the cohort examined. If these results hold true in other populations, then knowledge of SIPA1 SNP genotypes could potentially enhance current staging protocols.
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