ArticleThe Journal of cell biology1991
Association of Rab3A with synaptic vesicles at late stages of the secretory pathway.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 224 citations in OpenAlex.
- Assessing the Potential of NGF-Differentiated PC12 Cells as a Model for Synaptic Transmission.Molecular neurobiology · 2025Article
- Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction.Frontiers in synaptic neuroscience · 2021Article
- Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.eLife · 2019Article
- Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome.PLoS genetics · 2018Article
- Rab10 Disruption Results in Delayed OPC Maturation.Cellular and molecular neurobiology · 2017Article
- Levetiracetam Affects Differentially Presynaptic Proteins in Rat Cerebral Cortex.Frontiers in cellular neuroscience · 2017Article
- Skeletal muscle calpain acts through nitric oxide and neural miRNAs to regulate acetylcholine release in motor nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton.The Journal of cell biology · 2012Article
- Regulation of synaptic vesicle docking by different classes of macromolecules in active zone material.PloS one · 2012Article
- Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans.PloS one · 2012Article
- The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.Visual neuroscience · 2011Review
- Impaired activity-dependent plasticity of quantal amplitude at the neuromuscular junction of Rab3A deletion and Rab3A earlybird mutant mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Role of Rab GTPases in membrane traffic and cell physiology.Physiological reviews · 2011Review
- Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals.Frontiers in cellular neuroscience · 2011Article
- How peptide hormone vesicles are transported to the secretion site for exocytosis.Molecular endocrinology (Baltimore, Md.) · 2008Review
- The role of Rab3a in secretory vesicle docking requires association/dissociation of guanidine phosphates and Munc18-1.PloS one · 2007Article
- A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?The EMBO journal · 2005Article
- Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules.Molecular and cellular biology · 2002Article
- Cholesterol-dependent interaction of syncollin with the membrane of the pancreatic zymogen granule.The Biochemical journal · 2001Article
- Neurosecretory granule formation in ligated axons: additional arguments for a local differentiation from a Golgi apparatus extension.The Histochemical journal · 2001Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Rab3A is a small GTP-binding protein highly concentrated on synaptic vesicles. Like other small GTP-binding proteins it is thought to cycle between a soluble and a membrane-associated state. To determine at which stage of the life cycle of synaptic vesicles rab3A is associated with their membranes, the localization of the protein in neurons and neuroendocrine cells at different developmental and functional stages was investigated. In all cases, rab3A was colocalized with synaptic vesicle markers at the cell periphery, but was absent from the Golgi area, suggesting that rab3A associates with vesicles distally to the Golgi complex and dissociates from vesicle membranes before they recycle to this region. Immunofluorescence experiments carried out on frog motor end plates demonstrated that massive exocytosis of synaptic vesicles is accompanied by a translocation of rab3A to the cell surface. The selective localization of rab3A on synaptic vesicles at stages preceding their fusion with the plasmalemma suggests that the protein is part of a regulatory machinery that is assembled onto the vesicles in preparation for exocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.