ArticleThe Journal of cell biology1991
Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 201 citations in OpenAlex.
- Application of FRET Biosensors in Mechanobiology and Mechanopharmacological Screening.Frontiers in bioengineering and biotechnology · 2020Review
- BRET-monitoring of the dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation.Biochimica et biophysica acta · 2016Article
- RISAP is a TGN-associated RAC5 effector regulating membrane traffic during polar cell growth in tobacco.The Plant cell · 2014Article
- An apical actin-rich domain drives the establishment of cell polarity during cell adhesion.Histochemistry and cell biology · 2012Article
- Attachment of HeLa cells during early G1 phase.Histochemistry and cell biology · 2011Article
- Novel role of cPLA(2)alpha in membrane and actin dynamics.Cellular and molecular life sciences : CMLS · 2010Article
- Phosphoinositide-specific phospholipase C in oat roots: association with the actin cytoskeleton.Planta · 2009Article
- Diacylglycerol Kinase Inhibition and Vascular Function.Current enzyme inhibition · 2009Article
- Distribution of inositol 1,4,5-trisphosphate receptors in rat osteoclasts.Acta histochemica et cytochemica · 2008Article
- Phospholipase D signaling: orchestration by PIP2 and small GTPases.Naunyn-Schmiedeberg's archives of pharmacology · 2007Review
- Palmitoylation is required for efficient Fas cell death signaling.The EMBO journal · 2007Article
- Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation.The Journal of cell biology · 2004Article
- Diacylglycerol kinase theta is translocated and phosphoinositide 3-kinase-dependently activated by noradrenaline but not angiotensin II in intact small arteries.The Biochemical journal · 2001Article
- The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase.Molecular and cellular biology · 2000Article
- Muscarinic receptor activation promotes the membrane association of tubulin for the regulation of Gq-mediated phospholipase Cbeta(1) signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Actin Filaments Modulate Both Stomatal Opening and Inward K+-Channel Activities in Guard Cells of Vicia faba L.Plant physiology · 1997Article
- Signal transduction through epidermal growth factor receptor is altered in HeLa monolayer cells during mitosis.The Biochemical journal · 1997Article
- Purification and characterization of sn-1-stearoyl-2-arachidonoylglycerol kinase from pig testes.The Biochemical journal · 1997Article
- Aggregation-dependent, integrin-mediated increases in cytoskeletally associated PtdInsP2 (4,5) levels in human platelets are controlled by translocation of PtdIns 4-P 5-kinase C to the cytoskeleton.The EMBO journal · 1996Article
- Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase.Molecular biology of the cell · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we demonstrate that cytoskeletons isolated from A431 cells have associated with them high activities of several kinases involved in inositol lipid metabolism, such as phosphatidylinositol kinase, phosphatidylinositol phosphate kinase, and diacylglycerol kinase. In addition also phospholipase C activity was detected on isolated cytoskeletons. Controlled extraction of the cytoskeletons followed by in vitro polymerization of actin demonstrated an association of the kinases to the actin filament system consisting of actin and a number of actin-binding proteins. The cytoskeleton-associated lipid kinase activities were significantly increased upon treatment of intact cells with EGF. These data suggest that the association of the phosphoinositide kinases, diacylglycerol kinase, phospholipase C, and also the EGF receptor to the cytoskeleton may play a role in the efficient signal transduction induced by EGF, by providing a matrix for the various components involved in signal transduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.