ArticleKidney international2006
Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects.
Article in Kidney international, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00528580 (Statins for the Early Treatment of Sepsis), which is not on this map. Cited by 100 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Statins for the Early Treatment of Sepsis
Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it, 206 citations in OpenAlex.
- Targeting capillary leak in experimental sepsis and endotoxemia: a systematic review of therapeutic agents, methods and models in animal studies.Critical care (London, England) · 2026Pooled it
- Trial
- Statin exposure after multiple myeloma diagnosis and risk of all-cause mortality, venous thromboembolism, pathological fractures, and acute kidney injury: a propensity score-matched retrospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Association of Presepsis Statin Prescription With Kidney and Mortality Outcomes: Cause-Specific, Overlap-Weighted Analyses.Kidney medicine · 2026Article
- Continuous Antithrombin III Infusion in a Clinically Relevant Sepsis Model.Shock (Augusta, Ga.) · 2026Article
- Immune molecular mechanisms of PANoptosis in sepsis-induced acute kidney injury.Inflammation and regeneration · 2026Review
- Preventative effect of montelukast in mild to moderate contrast-induced acute kidney injury in rats via NADPH oxidase 4, p22phox and nuclear factor kappa-B expressions.International urology and nephrology · 2025Article
- Effect of atorvastatin as a renal protective agent in patients with systemic inflammatory response syndrome using the renal arterial resistive index.Acute and critical care · 2025Article
- Association of statin use with 28-day mortality in the Medical Information Mart for Intensive Care IV database: a retrospective cohort study.Journal of thoracic disease · 2025Article
- The impact of early use of statin in sepsis patients with acute kidney injury: a study based on MIMIC-IV.Frontiers in pharmacology · 2025Article
- The association of statin use with in-hospital mortality in patients with acute kidney injury during hospitalization: A retrospective analysis.Nephrology (Carlton, Vic.) · 2024Article
- Rapamycin mitigates organ damage by autophagy-mediated NLRP3 inflammasome inactivation in sepsis.Histology and histopathology · 2024Article
- Determination of trace elements and electrolyte levels in kidney tissue of simvastatin-treated septic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Association of statin use after renal replacement therapy with mortality in patients with dialysis-requiring acute kidney injury.International urology and nephrology · 2024Article
- Effects of statins beyond lipid-lowering agents in ART-treated HIV infection.Frontiers in immunology · 2024Review
- The renoprotective effects of taurine against diabetic nephropathy via the p38 MAPK and TGF-β/Smad2/3 signaling pathways.Amino acids · 2023Article
- BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils.The Journal of clinical investigation · 2023Article
- Association of Prior to Intensive Care Unit Statin Use With Outcomes on Patients With Acute Kidney Injury.Frontiers in medicine · 2021Article
- Article
- Protective Effects of Simvastatin on Endotoxin-Induced Acute Kidney Injury through Activation of Tubular Epithelial Cells' Survival and Hindering Cytochrome C-Mediated Apoptosis.International journal of molecular sciences · 2020Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Acute kidney injury (AKI) occurs in about half of patients in septic shock and the mortality of AKI with sepsis is extremely high. An effective therapeutic intervention is urgently required. Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors that also have pleiotropic actions. They have been reported to increase the survival of septic or infectious patients. But the effect of simvastatin, a widely used statin, on sepsis-induced AKI is unknown. The effects of simvastatin and tumor necrosis factor (TNF)-alpha neutralizing antibody were studied in a clinically relevant model of sepsis-induced AKI using cecal ligation and puncture (CLP) in elderly mice. Simvastatin significantly improved CLP-induced mortality and AKI. Simvastatin attenuated CLP-induced tubular damage and reversed CLP-induced reduction of intrarenal microvascular perfusion and renal tubular hypoxia at 24 h. Simvastatin also restored towards normal CLP-induced renal vascular protein leak and serum TNF-alpha. Neither delayed simvastatin therapy nor TNF-alpha neutralizing antibody improved CLP-induced AKI. Simvastatin improved sepsis-induced AKI by direct effects on the renal vasculature, reversal of tubular hypoxia, and had a systemic anti-inflammatory effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.