Evidence map›Paper›PMID 16556792›Full record

ArticleBritish journal of sports medicine2006

Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of Lactobacillus acidophilus.

R L Clancy, M Gleeson, A Cox, R Callister, M Dorrington, C D'Este, G Pang, D Pyne, P Fricker, A Henriksson

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of sports medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04530929 (Analysis of the Impact of Used Probiotic Strains and Diet on Body Composition, Cardiopulmonary Efficiency and the Incidence of Gastrointestinal Disorders in Runners), which is not on this map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04530929 nacompletednot on this mapstarted 2018, after this paper: background citation

Analysis of the Impact of Used Probiotic Strains and Diet on Body Composition, Cardiopulmonary Efficiency and the Incidence of Gastrointestinal Disorders in Runners

TypeinterventionalSponsorMedical University of BialystokRan2018 to 2018Enrolled66ConditionsGastrointestinal Disorder, FunctionalArmsSANPROBI BARRIER, PLACEBO
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 108 citations in OpenAlex.

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  7. Does Multi-Strain Probiotic Supplementation Impact the Effort Capacity of Competitive Road Cyclists?International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

R L ClancyDepartment of Immunology and Microbiology, University of Newcastle, NSW, Australia. robert.clancy@newcastle.edu.au
M Gleeson
A Cox
R Callister
M Dorrington
C D'Este
G Pang
D Pyne
P Fricker
A Henriksson
University of Newcastle Australia · AUJohn Hunter Hospital · AUAustralian Sports Commission · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatigue and impaired performance in athletes is well recognised and has been loosely linked to "overtraining". Reduced concentration of IgA in the saliva and increased shedding of Epstein Barr virus (EBV) have been associated with intense training in elite athletes.

objectiveTo determine whether athletes presenting with fatigue and impaired performance had an immune defect relevant to defective containment of EBV infection, and whether a probiotic preparation (Lactobacillus acidophilus) shown to enhance mucosal immunity in animal models could reverse any detected abnormality.

resultsThe fatigued athletes had clinical characteristics consistent with re-activation of EBV infection and significantly (p = 0.02) less secretion of interferon (IFN) gamma from blood CD4 positive T cells. After one month of daily capsules containing 2 x 10(10) colony forming units of L acidophilus, secretion of IFNgamma from T cells had increased significantly (p = 0.01) to levels found in healthy control athletes. A significant (p = 0.03) increase in salivary IFNgamma concentrations in healthy control athletes after the one month course of L acidophilus demonstrated in man the capacity for this probiotic to enhance the mucosal IFNgamma concentration.

conclusionThis is the first evidence of a T cell defect in fatigued athletes, and of its reversal following probiotic therapy.

Indexed as

Lactobacillus acidophilusAdolescentAdultCD4-Positive T-LymphocytesDrug EvaluationEpstein-Barr Virus InfectionsFatigueFemaleHerpesvirus 4, HumanHumansInterferon-gammaLeukocyte DisordersMalePhysical FitnessProbioticsSalivaInterferon-gamma

Identifiers

PMID16556792
PMCPMC2577537
OpenAlexW2139170289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.