Trial reportArchives of disease in childhood2006
Micronutrients (including zinc) reduce diarrhoea in children: the Pakistan Sprinkles Diarrhoea Study.
Trial report in Archives of disease in childhood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review.Nutrients · 2020Pooled it
- Point-of-use fortification of foods with micronutrient powders containing iron in children of preschool and school-age.The Cochrane database of systematic reviews · 2017Pooled it
- Oral zinc for treating diarrhoea in children.The Cochrane database of systematic reviews · 2016Pooled it
- Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries.Maternal & child nutrition · 2008Pooled it
- Micronutrient powder supplements combined with nutrition education marginally improve growth amongst children aged 6-23 months in rural Burkina Faso: A cluster randomized controlled trial.Maternal & child nutrition · 2019Trial
- The effect of providing lipid-based nutrient supplements on morbidity in rural Malawian infants and young children: a randomized controlled trial.Public health nutrition · 2016Trial
- Effects of community-based sales of micronutrient powders on morbidity episodes in preschool children in Western Kenya.The American journal of clinical nutrition · 2016Trial
- Trial
- Adding multiple micronutrient powders to a homestead food production programme yields marginally significant benefit on anaemia reduction among young children in Nepal.Maternal & child nutrition · 2015Trial
- The Long Term Impact of Micronutrient Supplementation during Infancy on Cognition and Executive Function Performance in Pre-School Children.Nutrients · 2015Trial
- The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children.European journal of clinical nutrition · 2012Trial
- The medium-term impact of a micronutrient powder intervention on anemia among young children in Rural China.BMC public health · 2024Article
- Postbiotics: Current Trends in Food and Pharmaceutical Industry.Foods (Basel, Switzerland) · 2022Review
- Postbiotics and Kidney Disease.Toxins · 2022Review
- Postbiotics: The concept and their use in healthy populations.Frontiers in nutrition · 2022Article
- Term Infant Formulas Influencing Gut Microbiota: An Overview.Nutrients · 2021Review
- The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics.Nature reviews. Gastroenterology & hepatology · 2021Review
- Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond.International journal of molecular sciences · 2019Review
- Why is multiple micronutrient powder ineffective at reducing anaemia among 12-24 month olds in Colombia? Evidence from a randomised controlled trial.SSM - population health · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo examine the effect of the daily use of micronutrients (including zinc) or the same micronutrients plus heat inactivated lactic acid bacteria (LAB), on diarrhoea in children compared to placebo.
methodsA triple blind randomised clinical trial in an urban slum of Karachi, Pakistan. Micronutrients (including zinc), micronutrients (including zinc and LAB), or placebo, were provided daily for two months to 75 young children (aged 6-12 months) identified at high risk for diarrhoea related mortality on the basis of history of at least one episode of diarrhoea in the preceding two weeks. The longitudinal prevalence of diarrhoea was defined as the percentage of days a child had diarrhoea out of the days the child was observed.
resultsMean longitudinal prevalence of diarrhoea in the micronutrient-zinc group was 15% (SD = 10%) child-days compared to 26% (SD = 20%) child-days in the placebo group and 26% (SD = 19%) child-days in the micronutrient-zinc-LAB group. The difference between the micronutrient-zinc-LAB and placebo groups was not significant.
conclusionThe daily provision of micronutrients (including zinc) reduces the longitudinal prevalence of diarrhoea and thus may also reduce diarrhoea related mortality in young children; heat inactivated LAB has negative effects in these children.
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