ArticleBMC evolutionary biology2006
Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1.
Article in BMC evolutionary biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Variation in Intra-individual Lentiviral Evolution Rates: a Systematic Review of Human, Nonhuman Primate, and Felid Species.Journal of virology · 2019Pooled it
- Size, Composition, and Evolution of HIV DNA Populations during Early Antiretroviral Therapy and Intensification with Maraviroc.Journal of virology · 2018Trial
- Viral expansion after transfer is a primary driver of influenza A virus transmission bottlenecks.PLoS biology · 2025Article
- Viral expansion after transfer is a primary driver of influenza A virus transmission bottlenecks.bioRxiv : the preprint server for biology · 2025Article
- Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants.Nature communications · 2023Article
- Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals.Virus evolution · 2023Article
- Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants.bioRxiv : the preprint server for biology · 2022Article
- First complete-genome documentation of HIV-1 intersubtype superinfection with transmissions of diverse recombinants over time to five recipients.PLoS pathogens · 2021Article
- Quantifying between-Host Transmission in Influenza Virus Infections.Cold Spring Harbor perspectives in medicine · 2020Review
- A novel framework for inferring parameters of transmission from viral sequence data.PLoS genetics · 2018Article
- Genetic bottlenecks in intraspecies virus transmission.Current opinion in virology · 2018Review
- The Impact of IgG transplacental transfer on early life immunity.ImmunoHorizons · 2018Article
- HIV-1 subtype CRF01_AE and B differ in utilization of low levels of CCR5, Maraviroc susceptibility and potential N-glycosylation sites.Virology · 2017Article
- Article
- Bayesian codon substitution modelling to identify sources of pathogen evolutionary rate variation.Microbial genomics · 2016Article
- Estimation of evolutionary parameters using short, random and partial sequences from mixed samples of anonymous individuals.BMC bioinformatics · 2015Article
- Disentangling the impact of within-host evolution and transmission dynamics on the tempo of HIV-1 evolution.AIDS (London, England) · 2015Article
- Analysis of Bottlenecks in Experimental Models of Infection.PLoS pathogens · 2015Review
- Bayesian inference of infectious disease transmission from whole-genome sequence data.Molecular biology and evolution · 2014Article
- The genealogical population dynamics of HIV-1 in a large transmission chain: bridging within and among host evolutionary rates.PLoS computational biology · 2014Article
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7 authors.
Funding
Abstract
backgroundGenetic diversity of the human immunodeficiency virus type 1 (HIV-1) population within an individual is lost during transmission to a new host. The demography of transmission is an important determinant of evolutionary dynamics, particularly the relative impact of natural selection and genetic drift immediately following HIV-1 infection. Despite this, the magnitude of this population bottleneck is unclear.
resultsWe use coalescent methods to quantify the bottleneck in a single case of homosexual transmission and find that over 99% of the env and gag diversity present in the donor is lost. This was consistent with the diversity present at seroconversion in nine other horizontally infected individuals. Furthermore, we estimated viral diversity at birth in 27 infants infected through vertical transmission and found there to be no difference between the two modes of transmission.
conclusionAssuming the bottleneck at transmission is selectively neutral, such a severe reduction in genetic diversity has important implications for adaptation in HIV-1, since beneficial mutations have a reduced chance of transmission.
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