Evidence map›Paper›PMID 16556257›Full record

ReviewImmunology2006

Drinking a lot is good for dendritic cells.

Christopher C Norbury

Abstract readReview
In one paragraph

Review in Immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Aquaporins in Immune System.Advances in experimental medicine and biology · 2023
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. TBC1D3 regulates the payload and biological activity of extracellular vesicles that mediate tissue repair.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  19. The pervasiveness of macropinocytosis in oncological malignancies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Review
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Christopher C NorburyDepartment of Microbiology and Immunology, Penn State M.S. Hershey College of Medicine, Hershey, PA 17033, USA. ccn1@psu.edu

Funding

Pathways of Antigen Presentation to CD8 T Cells In VivoR01AI056094 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI NORBURY, CHRISTOPHER C · 2003 to 2013
$3.1M
Pathways of Antigen Presentation to CD8 T Cells In VivoR56AI056094 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI NORBURY, CHRISTOPHER C · 2008 to 2008
$384k
NIAID NIH HHS AI056094NIAID NIH HHS R01 AI056094NIAID NIH HHS R56 AI056094
6 · The paper itself

Abstract

Macropinocytosis is the actin-dependent formation of large vesicles, which allow the internalization of large quantities of fluid-phase solute. In the majority of cells examined, an exogenous stimulus is required to induce the initiation of this endocytic pathway. However, dendritic cells are thought to constitutively macropinocytose large quantities of exogenous solute as part of their sentinel function. In this review we discuss the evidence that dendritic cells macropinocytose exogenous solute and subsequently present antigenic peptides derived from internalized material to T cells. In addition, we put these data into the context of immune surveillance in vivo.

Indexed as

Antigen PresentationBiological TransportCytoplasmic VesiclesDendritic CellsEndocytosisHumansPinocytosisViruses

Identifiers

PMID16556257
PMCPMC1782244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.