ArticleLipids2006
The real radical generator other than main-product hydroperoxide in lipid autoxidation.
Article in Lipids, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Primary Processes of Free Radical Formation in Pharmaceutical Formulations of Therapeutic Proteins.Biomolecules · 2023Review
- A Comparison of Different Tissues Identifies the Main Precursors of Volatile Substances in Chicken Meat.Frontiers in physiology · 2022Article
- Theoretical study of the impact of metal complexation on the reactivity properties of Curcumin and its diacetylated derivative as antioxidant agents.Journal of molecular modeling · 2021Article
- Evidence that Criegee intermediates drive autoxidation in unsaturated lipids.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition.Free radical biology & medicine · 2011Article
- Article
- Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation.The Journal of biological chemistry · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The theory of initiation in lipid autoxidation, which deals with the supply of radicals to the chain reaction, has not been substantively advanced for several decades. Most researchers have long assumed a mechanism of initiation in which main-product hydroperoxide is centrally responsible for autocatalytic radical generation. However, this paper, in which we investigate autoxidizing methyl linoleate, presents decisive evidence against such an assumption: Autoxidation-accelerating activity under mild conditions was not found in the chromatographically separated main-product hydroperoxide fraction but was found in other fractions; and highly active substances with structures containing a peroxide-linked dimer with two hydroperoxy groups were actually obtained.
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Identifiers
16555477What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.