ArticleJournal of medical virology2006
Enhanced identification of viral and atypical bacterial pathogens in lower respiratory tract samples with nucleic acid amplification tests.
Article in Journal of medical virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial.BMC medicine · 2011Trial
- Virus detection in critically ill children with acute respiratory disease: a new profile in view of new technology.Acta paediatrica (Oslo, Norway : 1992) · 2018Article
- Comparison of Luminex xTAG® RVP fast assay and real time RT-PCR for the detection of respiratory viruses in adults with community-acquired pneumonia.Journal of medical virology · 2016Article
- Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE): epidemiology, emerging organisms, and economics.BMC pediatrics · 2015Article
- Epidemiology of respiratory viruses in bronchoalveolar lavage samples in a tertiary hospital.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Article
- Coronavirus infections in hospitalized pediatric patients with acute respiratory tract disease.BMC infectious diseases · 2012Article
- Respiratory viral infections in pediatric solid organ and hematopoietic stem cell transplantation.Current infectious disease reports · 2012Article
- Evaluation of the Cepheid Xpert Flu Assay for rapid identification and differentiation of influenza A, influenza A 2009 H1N1, and influenza B viruses.Journal of clinical microbiology · 2012Article
- Updates in the relationship between human rhinovirus and asthma.Allergy, asthma & immunology research · 2012Article
- Evaluation of the PrimerDesign™ genesig real-time reverse transcription-polymerase chain reaction assay and the INFINITI® Respiratory Viral Panel Plus assay for the detection of human metapneumovirus in Kuwait.Diagnostic microbiology and infectious disease · 2012Article
- HOPE-BAL: improved molecular diagnostics by application of a novel technique for fixation and paraffin embedding.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Comparison of the Eragen Multi-Code Respiratory Virus Panel with conventional viral testing and real-time multiplex PCR assays for detection of respiratory viruses.Journal of clinical microbiology · 2010Article
- Detection of respiratory viruses and the associated chemokine responses in serious acute respiratory illness.Thorax · 2010Article
- Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens-duration of symptoms significantly affects detection rate.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010Article
- Enhanced viral etiological diagnosis of respiratory system infection outbreaks by use of a multitarget nucleic acid amplification assay.Journal of clinical microbiology · 2009Article
- Article
- Assay for 5' noncoding region analysis of all human rhinovirus prototype strains.Journal of clinical microbiology · 2008Article
- Comparison of the Luminex xTAG respiratory viral panel with in-house nucleic acid amplification tests for diagnosis of respiratory virus infections.Journal of clinical microbiology · 2008Article
- Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay.Journal of medical virology · 2008Article
- Use of throat swab or saliva specimens for detection of respiratory viruses in children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advantages of nucleic acid amplification tests (NAT) over conventional methods for the detection of pathogens in lower respiratory tract samples have not been established. NAT for respiratory pathogens were performed on 439 endotracheal tube (ETT) and bronchoalveolar lavage (BAL) samples. A potential pathogen was detected in 87 samples. Of 22 samples that tested positive by conventional methods, 15 tested positive for the same pathogen by NAT, 1 tested positive for a different pathogen, 2 had co-infections identified only by NAT, and 4 tested negative by NAT. An additional 73 pathogens were detected by NAT in 65 samples including 30 pathogens that were missed by conventional methods (19 adenovirus, 6 respiratory syncytial virus, 3 parainfluenza virus 1-4, 2 influenza A), 41 pathogens not routinely identified by conventional methods in most laboratories (23 rhinovirus, 8 human coronavirus OC43, 5 human metapneumovirus (hMPV), 2 human coronavirus 229E, 2 human coronavirus NL63, 1 Chlamydophila pneumoniae) and 2 pathogens from samples where no respiratory virus testing was requested (1 influenza A, 1 parainfluenza virus). Four of 52 patients who had multiple BAL samples submitted on the same day had negative and positive results by NAT on different samples. NAT improves detection of potential pathogens from ETT and BAL samples.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.