ArticleExperientia1991
Vitamin D receptors in heart: effects on atrial natriuretic factor.
Article in Experientia, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Effects of vitamin D on parathyroid hormone and clinical outcomes in peritoneal dialysis: a narrative review.Journal of nephrology · 2014Pooled it
- Tricuspid Valve Is Transcriptionally Active During Prolonged Pressure Overload, Right-Sided Heart Failure, and Valve Regurgitation.Journal of the American Heart Association · 2026Article
- Observational
- The effect of oral vitamin D on serum level of N-terminal pro-B-type natriuretic peptide.Advanced biomedical research · 2014Article
- Cardiorenal syndrome and vitamin D receptor activation in chronic kidney disease.Kidney research and clinical practice · 2012Review
- Association of 25-hydroxyvitamin D deficiency with NT-pro BNP levels in patients with acute myocardial infarction: a cross-sectional analysis.BMC research notes · 2011Article
- Serum 25-hydroxyvitamin D is not related to cardiac natriuretic peptide in nulliparous and lactating women.BMC endocrine disorders · 2009Article
- Vitamin D sites and mechanisms of action: a histochemical perspective. Reflections on the utility of autoradiography and cytopharmacology for drug targeting.Histochemistry and cell biology · 1995Review
- 1,25-Dihydroxyvitamin D3 binding sites in the eye and associated tissues of the green lizard Anolis carolinensis.The Histochemical journal · 1995Article
- Distribution of 1,25-dihydroxyvitamin D3[22-oxa] in vivo receptor binding in adult and developing skin.Archives of dermatological research · 1995Article
- Distribution of the nuclear receptor for vitamin D in female and male zebra finches, Taeniopygia guttata.Cell and tissue research · 1994Article
- Vitamin D3 (soltriol) nuclear receptors in abdominal scent gland and skin of Siberian hamster (Phodopus sungorus) localized by autoradiography and immunohistochemistry.Histochemistry · 1993Article
- Nuclear receptor sites for vitamin D-soltriol in midbrain and hindbrain of Siberian hamster (Phodopus sungorus) assessed by autoradiography.Histochemistry · 1992Article
- Vitamin D and the digestive system.European journal of drug metabolism and pharmacokineticsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report that receptors for vitamin D exist in distinct regions of the heart in female and male mice, predominantly in the right atrium where most of the cardial atrial natriuretic peptide (ANF) is produced. Tritiated 1,25-dihydroxyvitamin D3 (1,25-D3, vitamin D, soltriol) and ANF are colocalized in nuclei and cytoplasm respectively in identical cardiomyocytes. Changes of ANF tissue and blood levels under dietary deficiency and treatment with 1,25-D3 suggest direct genomic actions of vitamin D on myoendocrine cells of the atrium for the regulation of ANF manufacture and secretion. These results were obtained by combining thaw-mount autoradiography with immunocytochemistry using tritiated 1,25-D3 and an antibody against rat ANF. This antibody was also used in a radioimmunoassay to determine atrial natriuretic factor in plasma, atria and ventricles of normal or vitamin D-deficient mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.