ArticlePediatric surgery international2006
Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver.
Article in Pediatric surgery international, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
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- Leflunomide Treatment Does Not Protect Neural Cells following Oxygen-Glucose Deprivation (OGD) In Vitro.Cells · 2024Article
- Taurine Protects Doxorubicin-Induced Hepatotoxicity via Its Membrane-Stabilizing Effect in Rats.Life (Basel, Switzerland) · 2023Article
- Saffron nephroprotective effects against medications and toxins: A review of preclinical data.Iranian journal of basic medical sciences · 2022Review
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- Thyme Oil and Thymol Counter Doxorubicin-Induced HepatotoxicityOxidative medicine and cellular longevity · 2022Article
- Teriflunomide - The common drug with underestimated oxygen - Dependent anticancer potential.Biochemistry and biophysics reports · 2021Article
- Sufentanil Protects the Liver from Ischemia/Reperfusion-Induced Inflammation and Apoptosis by Inhibiting ATF4-Induced TP53BP2 Expression.Inflammation · 2021Article
- The role of exogenous epidermal growth factor on Ki-67 proliferation marker expression in the submandibular salivary gland of albino rats receiving doxorubicin.F1000Research · 2020Article
- Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats.Iranian journal of basic medical sciences · 2019Article
- Doxorubicin induced nephrotoxicity: protective effect of nicotinamide.International journal of cell biology · 2011Article
- Effect of leflunomide on liver regeneration after partial hepatectomy in rats.Pediatric surgery international · 2010Article
- Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion.Digestive diseases and sciences · 2010Article
- Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Does leflunomide attenuate the sepsis-induced acute lung injury?Pediatric surgery international · 2008Article
- Protection of Veratrum nigrum L. var. ussuriense Nakai alkaloids against ischemia-reperfusion injury of the rat liver.World journal of gastroenterology · 2007Article
- Hepatic damage in biliary-obstructed rats is ameliorated by leflunomide treatment.Pediatric surgery international · 2006Article
- Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation.Oxidative medicine and cellular longevityArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic ischemia-reperfusion (I/R) injury may be developed in some conditions, such as trauma, major hepatic resection, hemorrhagic shock or liver transplantation. I/R injury of the liver causes hepatocellular damage that may lead to hepatic failure. A considerable body of evidence indicates that reactive oxygen species (ROS) and inflammation may contribute to hepatocellular injury in liver I/R. Leflunomide is an isoxazole derivative, and a unique immunomodulatory agent. In the present study, we examined the effects of leflunomide on the neutrophil activation with oxidative stress and some antioxidant enzymes in the reperfusion following I/R in the rat liver. Thirty-two rats divided into four groups: group 1 (control); was given leflunomide 10 mg/kg, i.g.; group 2 (SHAM), animals were only laparotomized; group 3 (liver I/R), and group 4 (liver I/R + Leflunomide). In group 4, rats were pretreated with leflunomide (10 mg/kg, i.g.) two doses prior to experiment. In groups 3 and 4, occluding the hepatic pedicel for 60 min induced ischemia and reperfusion was allowed thereafter for 60 min. At the end of the reperfusion period, rats were sacrificed. superoxide dismutase, catalase, nitric oxide, xanthine oxidase, malondialdehyde, protein carbonyl and myeloperoxidase levels were determined in hepatic tissue as well as histological examination with H and E staining. Group 3 animals demonstrated severe deterioration of liver morphology and a significant liver oxidative stress. Pretreatment of animals with leflunomide markedly attenuated morphological alterations and neutrophil activation, reduced elevated oxidative stress products levels and restored the depleted hepatic antioxidant enzyme. The findings imply that ROS play a causal role in I/R-induced hepatic injury, and leflunomide exerts hepatoprotective effects probably by the anti-inflammatory effect with radical scavenging and antioxidant activities.
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