Trial reportChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2006
Pinealoblastomas in children.
Trial report in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Surgical management of pediatric pineal region tumors: an overview of current strategies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- Surgical management of pineal region tumors in Italy: a SINch (SINch®) National Survey with systematic review.Neurosurgical review · 2026Pooled it
- Neurosurgical management of pineal lesions: Insights from a single-center study of 27 cases.BioMedicine · 2026Article
- Recent Advances in Pineoblastoma Research: Molecular Classification, Modelling and Targetable Vulnerabilities.Cancers · 2025Review
- Prognostic factors of pediatric pineal region tumors at a single institution.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Review
- Tumor-related hydrocephalus in infants: a narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Adverse Factors of Treatment Response and Overall Survival in Pediatric and Adult Patients with Pineoblastoma.Cancer management and research · 2020Article
- Molecular Classification and Management of Rare Pediatric Embryonal Brain Tumors.Current oncology reports · 2018Review
- Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature.Oncology letters · 2015Article
- Sarcoidosis of the pineal gland: an unusual presentation of neurosarcoidosis.Journal of neuro-oncology · 2009Article
- Endoscopic biopsy during third ventriculostomy in paediatric pineal region tumours.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2008Article
- Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy.Journal of neuro-oncology · 2008Article
- [Supratentorial tumors].Der Radiologe · 2007Review
- [Intracranial tumors in pediatric patients].Der Radiologe · 2007Review
- Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeries of pinealoblastomas (PB) usually comprise small number of cases as this tumor type is extremely rare and occurs mainly in childhood (especially under 9 years of age). Frequently, PB are reported together with others pineal parenchymal tumors (PPT) or pineal tumors, making characterization far from adequate. MATERIALS AND
methodsOur series of CNS pediatric tumors comprises 1,350 cases of whom 16 are PPT, 12 PB, two pineocytomas (PC), and two mixed or transitional tumors (PC/PB). We have only analyzed the PB considering clinical features, treatment strategy, prognosis, recurrences, and mortality.
resultsPB represented 0.89%. Mean age was 7 years. Male-female ratio was 8/4. All patients complained of increased intracranial pressure, eight presented ocular symptoms, two cerebellar, and one endocrine disturbances. Patients underwent CT scans and/or MRI. All children had negative serum and CSF markers and only one case had positive tumor cells in the CSF on admission. Hydrocephalus (12/12) was treated with ventriculoperitoneal shunt in 11/12 and endoscopic third ventriculostomy (ETV) in 1/12. We performed 11 surgical procedures (seven by occipital transtentorial approach) and one endoscopic biopsy. Total removal was achieved in two, partial removal (50-90%) in seven, and biopsy in three patients or <50%. Adjuvant therapy included radiotherapy and chemotherapy. Recurrences appeared in 8/12 cases (mean time of recurrence=27.28 months). Six patients died (mean survival=29.55 months). Mean follow up for the six patients alive was 54 months and mean follow up for all 12 children was 38.7 months.
conclusionIn our opinion, PB have a poor prognosis and are very aggressive, especially in small children. Survival rate at 1 and 5 years in the present series is 66.6% (8/12) and 50% (6/12), respectively. We propose an algorithm for the treatment of pediatric patients with PB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.