Evidence map›Paper›PMID 16554839›Full record

ArticleGene therapy2006

Oncolysis of pancreatic tumour cells by a gamma34.5-deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway.

F Sarinella, A Calistri, P Sette, G Palù, C Parolin

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Gene therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Perspectives on immunotherapy via oncolytic viruses.Infectious agents and cancer · 2019
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Oncolytic viruses & their specific targeting to tumour cells.The Indian journal of medical research · 2012
    Review
  10. Oncolytic virotherapy for ovarian cancer.Oncolytic virotherapy · 2012
    Article
  11. Article
  12. Article
  13. Oncolytic virotherapy for pancreatic cancer.Expert reviews in molecular medicine · 2011
    Review
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

F SarinellaDepartment of Histology, Microbiology and Medical Biotechnologies, Section of Microbiology and Virology, Medical School, University of Padua, Padua, Italy.
A Calistri
P Sette
G Palù
C Parolin
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of viruses to selectively target, replicate within, and destroy tumour cells without deleterious effects in normal cells (oncolysis), makes the use of viruses as an attractive tool for cancer treatment. Pancreatic adenocarcinoma, being insensitive to traditional therapy and having a rather poor prognosis, represents a suitable target to evaluate viral oncolysis as a novel therapeutic approach. Herpes simplex virus (HSV) has been reported to produce an oncolytic effect in cells overexpressing Ras. As Ras signalling is frequently aberrant in pancreatic cancer, we compared four pancreatic cell lines (which differ in the presence of mutated or wild-type ras) for their ability to support growth of gamma34.5-replication attenuated HSV-1 (R3616). Our data show that permissiveness to viral replication is neither associated with enhanced Ras signalling nor with defective PKR activity. By contrast, we provide evidence that disregulation of the PI 3-kinase signalling pathway allows conditionally replication-defective R3616 virus to overcome the cellular antiviral activity.

Indexed as

AdenocarcinomaCell Line, TumorChromonesFlavonoidsGene DeletionGenes, rasGenetic TherapyHerpes SimplexHerpesvirus 1, HumanHumansImmunoblottingMitogen-Activated Protein Kinase KinasesMorpholinesOncolytic VirotherapyPancreatic NeoplasmsPhosphatidylinositol 3-Kinases2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneChromonesFlavonoidsgamma 34.5 protein, Human herpesvirus 1Mitogen-Activated Protein Kinase KinasesMorpholinesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsViral Proteins

Identifiers

PMID16554839
OpenAlexW2086703528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.